8A-AZALIDAS COMO AGENTES ANTIMICROBIANOS VETERINARIOS

• Main Authors: FARRINGTON, DANIEL O, WILKENING, ROBERT D, KROPP, HELMUT, RATCLIFFE, JEFFREY W, CLARK, JEFFREY N
• Format: Patent
• Language: Spanish
• Published: 13.03.2012
• Subjects: CHEMISTRY; DERIVATIVES THEREOF; HETEROCYCLIC COMPOUNDS; HUMAN NECESSITIES; HYGIENE; MEDICAL OR VETERINARY SCIENCE; METALLURGY; NUCLEIC ACIDS; NUCLEOSIDES; NUCLEOTIDES; ORGANIC CHEMISTRY; PREPARATIONS FOR MEDICAL, DENTAL, OR TOILET PURPOSES; SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS ORMEDICINAL PREPARATIONS; SUGARS

El uso de una 8a-azalida seleccionada de9desoxo-8a-aza-8a-homoeritromicina A;9-desoxo-8a-aza-8a-metil-8a-homoeritromicina A;9-desoxo-8a-aza-8a-etil-8a-5 homoeritromicina A;8a-(3-fenilpropil)-8a-aza-9-desoxo-8a-homoeritromicina A;9-desoxo-8a-aza-8a-alil-8a-homoeritromicina A;9-desoxo-8a-aza-8a-(prop-1-il)-8a-homoeritromicina A;9-desoxo-8a-aza-8a-(prop-1-iloxi)-8a-homoeritromicina A;9-desoxo-8a-aza-8a-(2-oxoet-1-il)-8a-homoeritromicina A;9-desoxo-8a-aza-8a-(2-hidroxiet-1-il)-8a-homoeritromicina A;9-desoxo-8a-aza-8a-((2,3-epoxi)prop-1-il)-8a-homoeritromicina A;9-desoxo-8a-aza-8a-(11-azetidinil)-2-et-il)-8a-homoeritromicina A;9-desoxo-8a-aza-8a-((1-pirrolidinil)-2-et-1-il)-8a-homoeritromicina A;9-desoxo-8a-aza-8a-((N-piperidinil)-2-et-1-il)-8a-homoeritromicina A;9-desoxo-8a-aza-8a-((4-morfolinil)-2-et-1-il)-8a-homoeritromicina A;9-desoxo-8a-aza-8a-((2-fluoroet-1-il)-2-aminoet-1-il)-8a-homoeritromicina A;8a-(2-cloroalil)-8a-aza-9-desoxo-8a-homoeritromicina A;8a-(2-fluoroalil)-8a-aza-9-desoxo-8a-homoeritromicina A;9-desoxo-8a-aza-8a-((2-ciano)et-1-il)-8a-homoeritromicina A;9-desoxo-8a-aza-8a-((3-amino) prop-1-il)-8a-homoeritromicina A;9-desoxo-8a-aza-8a-(((N, N-dimetil)-3-amino) prop-1-il)-8a-homoeritromicina A;9-desoxo-8a-aza-8a-((2-cianoetil)-3-aminoprop-1-il--8a-homoeritromicina A;9-desoxo-8a-aza-8a-((3,4-dihidroxibencil)-3-aminoprop-1-il)-8a-homoeritromicina A;-9-desoxo-8a-aza-8a-(3-acetoxiprop-1-il)-8a-homoeritromicina A;9-desoxo-8a-aza-8a-(3-hidroxiprop-1-il)-8a-homoeritromicina A;(3-metoxi-3-oxopropil)-8a-homoeritromicina A;8a-(3-octiloxi-3-oxopropil)-9-desoxo-8a-aza-8a-homoeritromicina A;8a-(3-(2-metoxietoxi)-3-oxopropil)-9-desoxo-8a-aza-8a-homoeritromicina A;8a-(3-isopropoxi-3-oxopropil)-9-desoxo-8a-aza-8a-homoeritromicina A;8a-(3-benciloxi-3-oxopropil)-9-desoxo-8a-aza-8a-homoeritromicina A;8a-(2-carboxietil)-9-desoxo-8a-aza-8a-homoeritromicina A;9-desoxo-8a-aza-8a-cianometil-8a-homoeritromicina A;9-desoxo-8a-aza-8a-(2-aminoetil)-8a-homoeritromicina A;9-desoxo-8a-aza-8a-(2-dimetilaminoetil)-8a-homoeritromicina A;9-desoxo-8a-aza-8a-(N-L-leucil-2-aminoetil)-8a-homoeritromicina A; 8a-Azalides are useful in the treatment and prevention of bacterial respiratory and enteric infections in livestock animals, particularly in cattle and swine.