FORMULACIONES ESTERILES QUE MODIFICAN LA RESPUESTA INMUNE Y METODOS

• Main Authors: TRUONG, MYHANH T, STATHAM, ALEXIS S, STOESZ, JAMES D
• Format: Patent
• Language: Spanish
• Published: 05.03.2012
• Subjects: CHEMICAL ASPECTS OF BANDAGES, DRESSINGS, ABSORBENT PADS, ORSURGICAL ARTICLES; DISINFECTION, STERILISATION, OR DEODORISATION OF AIR; HUMAN NECESSITIES; HYGIENE; MATERIALS FOR BANDAGES, DRESSINGS, ABSORBENT PADS, OR SURGICALARTICLES; MEDICAL OR VETERINARY SCIENCE; METHODS OR APPARATUS FOR STERILISING MATERIALS OR OBJECTS INGENERAL; PREPARATIONS FOR MEDICAL, DENTAL, OR TOILET PURPOSES

Una composición farmacéutica tópica que comprende un compuesto medicamento modificador de la respuesta inmune que es estable a la esterilización y apropiado para aplicación tópica directamente a sitios del tejido donde la dermis ha sido rota; caracterizada porque el compuesto medicamento es 1-(2-metilpropil)-1H-imidazo[4,5-c]quinolin- 4-amina (imiquimod) esterilizado por exposición a radiación de haz de electrones. A pharmaceutical composition comprising an active substance selected from the group consisting of imiquimod (1-(2-methylpropyl)-1 H -imidazo[4,5- c ]quinolin-4-amine), sotirimod(2-methyl-1-(2-methylpropyl)-1H-imidazo[4,5-c][1,5]naphthyridin-4-amine) and resiquimod (4-amino-±,±-dimethyl-2-ethoxymethyl-1H-imidazo[4,5-c]quinoline-1-ethanol), that is stable to sterilization and suitable for topical application directly to tissue sites where the dermis has been breached, and has been sterilized, packaged compositions that have been sterilized, and methods of sterilizing these compositions are disclosed.