CARBON NANOHORNS COMPRISING DENDRIMERS ON THEIR SURFACE AS NON -VIRAL VECTORS FOR GENE THERAPY

• Main Authors: RUBIO CARRERO, NOELIA, GUERRA NAVARRO, FCO. JAVIER, RODRIGUEZ LOPEZ, JULIAN, VAZQUEZ FERNANDEZ-PACHECO, ESTER, CAMPO RODRIGO, ANA, SANCHEZ VERDU, MARIA DEL PRADO, HERRERO CHAMORRO, MARIA ANTONIA, GARCIA MARTINEZ, JOAQUIN CALIXTO, PEREZ MARTINEZ, FRANCISCO, CENA CALLEJO, VALENTIN, MERINO GUIJARRO, SONIA
• Format: Patent
• Language: English; Spanish
• Published: 15.02.2012
• Subjects: BEER; BIOCHEMISTRY; CHEMISTRY; COMPOSITIONS THEREOF; CULTURE MEDIA; ENZYMOLOGY; HUMAN NECESSITIES; HYGIENE; MANUFACTURE OR TREATMENT OF NANOSTRUCTURES; MEASUREMENT OR ANALYSIS OF NANOSTRUCTURES; MEDICAL OR VETERINARY SCIENCE; METALLURGY; MICROBIOLOGY; MICROORGANISMS OR ENZYMES; MUTATION OR GENETIC ENGINEERING; NANOTECHNOLOGY; PERFORMING OPERATIONS; PREPARATIONS FOR MEDICAL, DENTAL, OR TOILET PURPOSES; PROPAGATING, PRESERVING OR MAINTAINING MICROORGANISMS; SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS ORMEDICINAL PREPARATIONS; SPECIFIC USES OR APPLICATIONS OF NANOSTRUCTURES; SPIRITS; TRANSPORTING; VINEGAR; WINE

The invention relates to novel non-viral vectors comprising at least one carbon nanohorn having, on the surface thereof, dendrons and/or dendrimers that are, in turn, linked to at least one biologically active molecule, for the use thereof in gene therapy and the use thereof for producing a medicament. The invention also relates to a method for the synthesis of said non-viral vectors. Vectores no virales para terapia génica.La presente invención se refiere a nuevos vectores no virales, que comprenden al menos un nanocuerno de carbono que comprende en su superficie dendrones y/o dendrimeros que a su vez están unidos con al menos una molécula biológicamente activa, para su uso en terapia génica y su uso para la elaboración de un medicamento. Además se describe el procedimiento de síntesis de dichos vectores no virales.