BIOSINTESIS DE DERIVADOS DE MONACOLINA J

The invention relates to a process for obtaining monacolin J derivatives (I), wherein R 1 is COR 2 , wherein R 2 is selected from C1-C15 alkyl, C3-C15 cycloalkyl, C2-C15 alkenyl, C2-C15 alkynyl, aryl and heterocyclyl; which comprises producing monacolin J by fermentation from a monacolin J-producing...

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Bibliographic Details
Main Authors ADRIO FONDEVILA, JOSE LUIS, CAMPOY GARCIA, SONIA, VELASCO ALVAREZ, JAVIER, ZAFRA GOMEZ, ALBERTO
Format Patent
LanguageSpanish
Published 10.06.2011
Subjects
BEER
BIOCHEMISTRY
CHEMISTRY
ENZYMOLOGY
FERMENTATION OR ENZYME-USING PROCESSES TO SYNTHESISE A DESIREDCHEMICAL COMPOUND OR COMPOSITION OR TO SEPARATE OPTICAL ISOMERSFROM A RACEMIC MIXTURE
HETEROCYCLIC COMPOUNDS
HUMAN NECESSITIES
HYGIENE
MEDICAL OR VETERINARY SCIENCE
METALLURGY
MICROBIOLOGY
MUTATION OR GENETIC ENGINEERING
ORGANIC CHEMISTRY
PREPARATIONS FOR MEDICAL, DENTAL, OR TOILET PURPOSES
PROCESSES USING MICROORGANISMS
SPIRITS
VINEGAR
WINE
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Summary:The invention relates to a process for obtaining monacolin J derivatives (I), wherein R 1 is COR 2 , wherein R 2 is selected from C1-C15 alkyl, C3-C15 cycloalkyl, C2-C15 alkenyl, C2-C15 alkynyl, aryl and heterocyclyl; which comprises producing monacolin J by fermentation from a monacolin J-producing microorganism; and acylating the hydroxyl group present in the C8 position of the monacolin J previously obtained by means of adding a suitable acylating agent to the fermentation medium to obtain the desired monacolin J derivative (I).
Bibliography:Application Number: ES20080002971