PRODUCCION DE UN FACTOR BIOLOGICO Y CREACION DE UN ENTORNO INMUNOLOGICAMENTE PRIVILEGIADO USANDO CELULAS DE SERTOLI ALTERADAS GENETICAMENTE

• Main Authors: HALBERSTADT, CRAIG, GORES, PAUL, SHAUN A. KIRKPATRICK
• Format: Patent
• Language: Spanish
• Published: 03.05.2010
• Subjects: BEER; BIOCHEMISTRY; CHEMISTRY; COMPOSITIONS THEREOF; CULTURE MEDIA; ENZYMOLOGY; HUMAN NECESSITIES; HYGIENE; MEDICAL OR VETERINARY SCIENCE; METALLURGY; MICROBIOLOGY; MICROORGANISMS OR ENZYMES; MUTATION OR GENETIC ENGINEERING; PREPARATIONS FOR MEDICAL, DENTAL, OR TOILET PURPOSES; PROPAGATING, PRESERVING OR MAINTAINING MICROORGANISMS; SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS ORMEDICINAL PREPARATIONS; SPIRITS; VINEGAR; WINE

Uso de células de Sertoli alteradas genéticamente para producir un factor biológico o intermedio del mismo y en el que dichas células de Sertoli crean un sitio inmunológicamente privilegiado para la producción de un medicamento para tratar una enfermedad en un sujeto causada por una deficiencia del factor biológico. The present invention provides a method of providing an individual with a biological factor or intermediate thereof which comprises introducing into the individual Sertoli cells genetically altered to produce the biological factor or intermediate thereof. The genetically altered Sertoli cells are administered in an amount effective to produce the desired effect. Aside from producing the biological factor or intermediate thereof, the engineered Sertoli cells also create an immunologically privileged site. Vectors comprising a promoter which functions in Sertoli cells operably linked to coding sequence for a desired biological factor are also provided as are Sertoli cells comprising such vectors. A pharmaceutical composition comprising Sertoli cells genetically altered to produce a biological factor is also provided.