COMPOSICIONES FARMACEUTICAS QUE CONTIENEN DERIVADOS DE NITROVINILFURANO PARA EL TRATAMIENTO DE LA LEISHMANIOSIS Y LA TRIPANOSOMIASIS

Composiciones farmacéuticas que contienen derivados de nitrovinilfurano para el tratamiento de la leishmaniosis y la tripanosomiasis. The present invention describes the action of a new family of drugs against a number of Leishmania species and Trypanosoma cruzi, for the treatment of cutaneous, muco...

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Main Authors MONZOTE FIDALGO, LIANET, INFANTE BOURZAC, JUAN, FRANCISCO, CASTANEDO CANCIO, NILO, RAMON, LOPEZ HERNANDEZ, YAMILE, MONTALVO ALVAREZ, ANA, MARGARITA, SIFONTES RODRIGUEZ, SERGIO
Format Patent
LanguageSpanish
Published 14.04.2010
Subjects
HUMAN NECESSITIES
HYGIENE
MEDICAL OR VETERINARY SCIENCE
PREPARATIONS FOR MEDICAL, DENTAL, OR TOILET PURPOSES
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Summary:Composiciones farmacéuticas que contienen derivados de nitrovinilfurano para el tratamiento de la leishmaniosis y la tripanosomiasis. The present invention describes the action of a new family of drugs against a number of Leishmania species and Trypanosoma cruzi, for the treatment of cutaneous, mucocutaneous and visceral leishmaniosis as well as tripanosomosis. In vitro assays and studies conducted in animal models and in human patients demonstrated that the compounds had a higher activity compared to drugs in clinical use against Leishmania mexicana amazonensis, L. donovani infantum, L. braziliensis braziliensis and Trypanosoma cruzi. The pharmaceutical activity of compositions based on such family of compounds was evidenced and supports its human and veterinary application for the treatment of the above-mentioned diseases by using different administration routes.
Bibliography:Application Number: ES20060791280T