COMPOSICION FARMACEUTICA PARA EL TRATAMIENTO DEL CANCER

The invention relates to compositions containing a first compound having TGF-ß1 inhibitory activity and a second compound in the form of an immune-stimulating cytokine, preferably IL-12 or a functionally equivalent variant of same. Said compositions demonstrate synergistic effects on antitumour prop...

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Main Authors LASARTE SAGASTIBELZA JUAN JOSE, RUIZ GUILLEN MARTA, RODRIGUEZ MADOZ JUAN ROBERTO, ALZUGUREN MAZA PILAR, HERNANDEZ ALCOCEBA RUBEN, SMERDOU PICAZO CRISTIAN
Format Patent
LanguageSpanish
Published 22.09.2010
Subjects
BEER
BIOCHEMISTRY
CHEMISTRY
COMPOSITIONS THEREOF
CULTURE MEDIA
ENZYMOLOGY
HUMAN NECESSITIES
HYGIENE
MEDICAL OR VETERINARY SCIENCE
METALLURGY
MICROBIOLOGY
MICROORGANISMS OR ENZYMES
MUTATION OR GENETIC ENGINEERING
PREPARATIONS FOR MEDICAL, DENTAL, OR TOILET PURPOSES
PROPAGATING, PRESERVING OR MAINTAINING MICROORGANISMS
SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS ORMEDICINAL PREPARATIONS
SPIRITS
VINEGAR
WINE
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Summary:The invention relates to compositions containing a first compound having TGF-ß1 inhibitory activity and a second compound in the form of an immune-stimulating cytokine, preferably IL-12 or a functionally equivalent variant of same. Said compositions demonstrate synergistic effects on antitumour properties when compared to components acting separately. The invention also relates to compositions containing the aforementioned compounds and to the medical use of same for the treatment of cancer, particularly hepatocellular carcinoma and gastrointestinal tumours.
Bibliography:Application Number: ES20080000417