COMPUESTOS CON PROPIEDADES DE LIBERACION DE LA HORMONA DEL CRECIMIENTO

• Main Authors: PESCHKE, BERND, HANSEN, THOMAS, KRUSE, WATSON, BRETT, LUNDT, BEHREND, FRIEDRICH, ANKERSEN, MICHAEL, LAU, JESPER
• Format: Patent
• Language: Spanish
• Published: 07.07.2009
• Subjects: ACYCLIC OR CARBOCYCLIC COMPOUNDS; CHEMISTRY; CORRECTION OF TYPOGRAPHICAL ERRORS; HETEROCYCLIC COMPOUNDS; HUMAN NECESSITIES; HYGIENE; i.e. MECHANISMS PRINTING OTHERWISE THAN FROM A FORME; LINING MACHINES; MEDICAL OR VETERINARY SCIENCE; METALLURGY; ORGANIC CHEMISTRY; PEPTIDES; PERFORMING OPERATIONS; PREPARATIONS FOR MEDICAL, DENTAL, OR TOILET PURPOSES; PRINTING; SELECTIVE PRINTING MECHANISMS; SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS ORMEDICINAL PREPARATIONS; STAMPS; TRANSPORTING; TYPEWRITERS

COMPUESTOS DE NATURALEZA MIMETICA A LOS PEPTIDOS QUE POSEEN LA FORMULA GENERAL (I), EN LA QUE A Y B VALEN INDEPENDIENTEMENTE 1 O 2, R 1 Y R 2 CORRESPONDEN INDEPENDIENTEMEN TE A UN H O C 1-6 ALQUILO, G Y J CORRESPONDEN INDEPENDIENTEMENTE, ENTRE OTROS, A COMPUESTOS AROMATICOS, Y D Y E CORRESPONDEN INDEPENDIENTEMENTE A VARIOS GRUPOS DIFERENTES, QUE SON ESTIMULADORES DE LA SECRECION DE HORMONA DEL CRECIMIENTO CON UNA BIODISPONIBILIDAD MEJORADA. Compounds of peptide mimetic nature having the general formula I wherein a and b are independently 1 or 2, R1 and R2 are independently H or C1-6alkyl, G and J are independently, inter alia, aromats, and D and E are independently several different groups are growth hormone secretagogous with improved bioavailability.