DERIVADOS DE N-(1H-INDOL-5-IL)NAFTALENO-1-SULFONAMIDA Y COMPUESTOS RELACIONADOS COMO ANTAGONISTAS DEL RECEPTOR DE SEROTONINA 5-HT6 PARA EL TRATAMIENTO DE TRASTORNOS DEL SISTEMA NERVIOSO CENTRAL

• Main Authors: ANDALUZ-MATARO, BLAS, FRIGOLA-CONSTANSA, JORDI, MERCE-VIDAL, RAMON
• Format: Patent
• Language: Spanish
• Published: 16.06.2009
• Subjects: CHEMISTRY; HETEROCYCLIC COMPOUNDS; HUMAN NECESSITIES; HYGIENE; MEDICAL OR VETERINARY SCIENCE; METALLURGY; ORGANIC CHEMISTRY; PREPARATIONS FOR MEDICAL, DENTAL, OR TOILET PURPOSES; SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS ORMEDICINAL PREPARATIONS

Un compuesto derivado de sulfonamida de fórmula general (I) **(Ver fórmula)** en la cual A representa un sustituyente seleccionado de entre: **(Ver fórmula)** R1 representa hidrógeno, un radical alquilo C 1-C 4 o un radical bencilo; n representa 0, 1, 2, 3 ó 4; R2 representa -NR4R5 o un grupo de fórmula: **(Ver fórmula)** R3, independientemente representan hidrógeno o alquilo C 1-C 4; R4 y R5 independientemente representan un alquilo C1-C4, X, Y y Z independientemente representan hidrógeno, flúor, cloro, bromo, alquilo C1-C4, alcoxi C1-C4, alquiltio C1-C4, trifluorometil, ciano, nitro y -NR 4R5; W representa un enlace entre los dos anillos, CH2, O, S y NR4; m representa 0, 1, 2, 3 ó 4; con la condición de que cuando m = 0, A es un fenilo sustituido; o una de sus sales fisiológicamente aceptables. The present invention provides new compounds with serotonin 5-HT6 receptor antagonistic activity useful in the preparation of a medicament for prevention or treatment of various disorders of the Central Nervous System, and in particular anxiety, depression, cognitive memory disorders and senile dementia or other dementia processes in which there is a predominant cognition deficit, psychosis, infantile hyperkinesia (ADHD, attention deficit / hyperactivity disorder) and other disorders mediated by the serotonin 5-HT 6 receptor in mammals, including man. The compounds object of the present invention have the general formula (I) wherein A represents a substituent selected from among: R 2 represents -NR 2 R 5 or a group with formula: the other substituents are specified in the claims.