ALZHEIMER'S DISEASE ANIMAL MODEL, METHOD FOR OBTAINING SAME AND USES THEREOF

• Main Authors: VALDIVIESO AMATE FERNANDO, MONTOLIU JOSE LLUIS, POZUETA LARIOS JULIO
• Format: Patent
• Language: English; Spanish
• Published: 01.04.2009
• Subjects: AGRICULTURE; ANIMAL HUSBANDRY; BEER; BIOCHEMISTRY; CARE OF BIRDS, FISHES, INSECTS; CHEMISTRY; COMPOSITIONS THEREOF; CULTURE MEDIA; ENZYMOLOGY; FISHING; FORESTRY; HUMAN NECESSITIES; HUNTING; METALLURGY; MICROBIOLOGY; MICROORGANISMS OR ENZYMES; MUTATION OR GENETIC ENGINEERING; NEW BREEDS OF ANIMALS; PROPAGATING, PRESERVING OR MAINTAINING MICROORGANISMS; REARING OR BREEDING ANIMALS, NOT OTHERWISE PROVIDED FOR; SPIRITS; TRAPPING; VINEGAR; WINE

The invention relates to a transgenic non-human animal which can be used as a non-human animal model for studying Alzheimer's disease (AD) and which is characterized in that : it contains a heterologous polynucleotide (transgene) which is inserted in the genome thereof and which comprises the nucleotide sequence of the complete human APP gene together with the regulatory sequences thereof and it has an endogenous expression pattern similar to that of the hAPP gene in humans. The inventive model can be used to study AD and in the screening of potentially-useful compounds for the prevention and/or treatment of AD. El animal no-humano transgénico útil como modelo animal no-humano para el estudio de la Enfermedad de Alzheimer (EA) se caracteriza porque contiene insertado en su genoma, un polinucleótido heterólogo (transgén) que comprende la secuencia de nucleótidos del gen APP humano completo junto con sus secuencias reguladoras, y presenta un patrón de expresión endógeno similar al patrón de expresión endógeno del gen hAPP en humanos. De aplicación en el estudio de la EA y en el screening de compuestos potencialmente útiles para la prevención y/o tratamiento de la EA.