DERIVADOS DE TIENOPIRIDAZINONA COMO MODULADORES DE ENFERMEDADES AUTOINMUNES

• Main Authors: COOPER, MARTIN E, RASUL, RUKHSANA T, GUILE, SIMON D, INGALL, ANTHONY H
• Format: Patent
• Language: Spanish
• Published: 16.03.2008
• Subjects: CHEMISTRY; HETEROCYCLIC COMPOUNDS; HUMAN NECESSITIES; HYGIENE; MEDICAL OR VETERINARY SCIENCE; METALLURGY; ORGANIC CHEMISTRY; PREPARATIONS FOR MEDICAL, DENTAL, OR TOILET PURPOSES

Un compuesto de fórmula (I): * en la cual: R1 es alquilo C1-6, alquenilo C2-6 o cicloalquilo C3-6 que está sustituido opcionalmente con alquilo C1-6, estando cada uno de estos R1 anteriores sustituido opcionalmente con uno o más átomos de halógeno: R2 es alquilo C1-6; R3 es un grupo CO-G o SO2-G donde G es un anillo de 5 ó 6 miembros que contiene un átomo de nitrógeno y un segundo heteroátomo seleccionado de oxígeno y azufre adyacente al nitrógeno, y sustituido opcionalmente con hasta 3 grupos seleccionados de hidroxilo y alquilo C1-4; Q es CR5R6 donde R5 es hidrógeno, alquilo C1-6 o flúor y R6 es hidrógeno, OH o flúor, o R5 y R6 forman juntos un grupo =O, con la salvedad de que R5 no puede ser flúor cuando R6 es OH; The invention relates to thienopyridazinones of formula (I): wherein: R1 is C1-6 alkyl, C2-6 alkenyl or C3-6 cycloalkyl which is optionally substituted by C1-6 alkyl, each of the above being optionally substituted by one or more halogen atoms; R2 is C1-6 alkyl; R3 is a group CO-G or SO2-G where G is a 5- or 6-membered ring containing a nitrogen atom and a second heteroatom selected from oxygen and sulphur adjacent to the nitrogen, and optionally substituted by up to 3 groups selected from hydroxyl and C1-4 alkyl; Q is CR5R6 where R5 and R6 are as defined in the specification; and R4 is a 5- to 10-membered mono- or bi-cyclic aromatic ring system, containing 0 to 4 heteroatoms independently selected from nitrogen, oxygen and sulphur, the ring system being optionally substituted as described in the specification, and pharmaceutically acceptable salts and solvates thereof. Processes for their preparation, pharmaceutical compositions containing them and their use in therapy, in particular in the modulation of autoimmune disease are also described.