NEW PYRIDO[3',2':4,5]FURO[3,2-d]PYRIMIDINE DERIVATIVES

• Main Authors: PAGES SANTACANA LLUIS MIQUEL, TALTAVULL MOLL JOAN
• Format: Patent
• Language: English; Spanish
• Published: 16.09.2007
• Subjects: CHEMISTRY; HETEROCYCLIC COMPOUNDS; HUMAN NECESSITIES; HYGIENE; MEDICAL OR VETERINARY SCIENCE; METALLURGY; ORGANIC CHEMISTRY; PREPARATIONS FOR MEDICAL, DENTAL, OR TOILET PURPOSES

The present invention provides a pyridofuropyrimidine derivative of formula (I): wherein G represents a group selected from -CR R - and -O- wherein R and R independently represent hydrogen atoms or C1-4 alkyl groups R and R are independently selected from hydrogen atoms and C1-4 alkyl groups R represents a group selected from C1-4 alkyl, C1-4 alkoxy, amino, hydroxy, mono- C1-4 alkylamino, di- C1-4 alkylamino, C3-8 cycloalkylamino, aryl, heteroaryl and saturated N-containing heterocyclyl groups which are bound to the pyridine ring through their nitrogen atom, all of them being optionally substituted by one or more substituents selected from the group consisting of halogen atoms and hydroxy, C1-4 alkyl, C1-4 alkoxy- C1-4 alkyl, aryl-C1-4 4alkyl, -O(CO)O R , C1-4 alkoxy, -(CO)NR R , -CN, -CF3, -NR R , -SR and -SO2NH2 groups wherein R and R each independently represent a hydrogen atom or a C1-4 alkyl group R and R are independently selected from the group consisting of hydrogen atoms, C1-4 alkyl groups, hydroxyl- C1-4 alkyl groups and groups of formula (II): wherein p and q are integers selected from 0, 1 , 2 and 3 A is either a direct bond or a group selected from -CONR -, -NR CO-, -0-, -COO-, -OCO-, -S-, -SO- and -SO2-, wherein each R , R , R , R and R independently represents a hydrogen atom or a C1-4 alkyl group and G is a group selected from aryl, heteroaryl or heterocyclyl groups wherein the group G is optionally substituted by one or more substituents selected from group consisting of halogen atoms and C1-4 alkyl, hydroxy, oxo, C1-4 alkoxy- C1-4 alkyl, aryl- C1-4 alkyl, -(CO)OR , C1-4 alkoxy, -(CO)NR R , -CN, -CF3, -NR R , -SR and -SO2NH2 groups wherein R and R each independently represent a hydrogen atom or a C1-4 alkyl group and the pharmaceutically acceptable salts and N-oxides thereof. La presente invención se refiere a nuevos derivados de piridofuropirimidina de fórmula I terapéuticamente útiles, a procedimientos para su preparación y a composiciones farmacéuticas que los contienen. Los valores de los diferentes radicales presentes en la fórmula I son los descritos en la memoria. Estos compuestos son inhibidores potentes y selectivos de la fosfodiesterasa 4 (PDE4), y son por tanto útiles en el tratamiento, la prevención o la supresión de afecciones patológicas, enfermedades y trastornos conocidos por ser susceptibles de mejora mediante la inhibición de PDE4.