BIBLIOTECAS COMBINATORIAS DE HIDRATOS DE CARBONO COMPLEJOS Y METODOS PARA LA PRODUCCION Y USOS DE LAS MISMAS

• Main Authors: DUKLER, AVINOAM, DOTAN, NIR
• Format: Patent
• Language: Spanish
• Published: 16.07.2007
• Subjects: APPARATUS THEREFOR; BEER; BIOCHEMISTRY; CHEMICAL OR PHYSICAL PROCESSES, e.g. CATALYSIS OR COLLOIDCHEMISTRY; CHEMISTRY; COMBINATORIAL CHEMISTRY; COMPOUNDS OF UNKNOWN CONSTITUTION; DERIVATIVES THEREOF; ENZYMOLOGY; FERMENTATION OR ENZYME-USING PROCESSES TO SYNTHESISE A DESIREDCHEMICAL COMPOUND OR COMPOSITION OR TO SEPARATE OPTICAL ISOMERSFROM A RACEMIC MIXTURE; GENERAL METHODS OF ORGANIC CHEMISTRY; INVESTIGATING OR ANALYSING MATERIALS BY DETERMINING THEIRCHEMICAL OR PHYSICAL PROPERTIES; LIBRARIES, e.g. CHEMICAL LIBRARIES, IN SILICOLIBRARIES; MEASURING; METALLURGY; MICROBIOLOGY; MUTATION OR GENETIC ENGINEERING; NUCLEIC ACIDS; NUCLEOSIDES; NUCLEOTIDES; ORGANIC CHEMISTRY; PERFORMING OPERATIONS; PHYSICAL OR CHEMICAL PROCESSES OR APPARATUS IN GENERAL; PHYSICS; SPIRITS; SUGARS; TESTING; THEIR RELEVANT APPARATUS; TRANSPORTING; VINEGAR; WINE

Biblioteca combinatoria de hidratos de carbono direccionable producida enzimáticamente in situ que comprende una pluralidad de estructuras de hidratos de carbono, uniéndose cada una a una posición específica y direccionable de un soporte sólido único plano, en la que cada una de dicha pluralidad de estructuras de hidratos de carbono se compone de monosacáridos, de tal modo que se define una estereoespecificidad de cada enlace que interconecta dichos hidratos de carbono por dicha posición direccionable sobre dicho soporte sólido único plano. The present invention concerns a carbohydrate library comprising a plurality of carbohydrate structures each being attached at a specific and addressable location of an array, whereas a stereo-specificity of each bond interconnecting said monosaccharide units of said plurality of carbohydrate structures is defined by said addressable location thereof on said array, as well as a method of generating a profile of antibodies against glyco-markers present in the blood serum of a subject.