BIOACTIVE PEPTIDE-PRODUCING STRAINS OF i ENTEROCOCCUS FAECALIS /i , BIOACTIVE PEPTIDES AND APPLICATIONS THEREOF

• Main Authors: MUGUERZA MARQUINEZ BEGONA, ALEIXANDRE DE ARTINANO MARIA AMAYA, RAMOS GONZALEZ MERCEDES, DELGADO DELGADO MARCO ANTONIO, RECIO SANCHEZ ISIDRA, QUIROS DEL BOSQUE ANA
• Format: Patent
• Language: English; Spanish
• Published: 01.07.2007
• Subjects: BEER; BIOCHEMISTRY; CHEMISTRY; COMPOSITIONS THEREOF; CULTURE MEDIA; ENZYMOLOGY; FERMENTATION OR ENZYME-USING PROCESSES TO SYNTHESISE A DESIREDCHEMICAL COMPOUND OR COMPOSITION OR TO SEPARATE OPTICAL ISOMERSFROM A RACEMIC MIXTURE; FOODS OR FOODSTUFFS; FOODS, FOODSTUFFS, OR NON-ALCOHOLIC BEVERAGES, NOT COVERED BYSUBCLASSES A23B - A23J; HUMAN NECESSITIES; HYGIENE; MEDICAL OR VETERINARY SCIENCE; METALLURGY; MICROBIOLOGY; MICROORGANISMS OR ENZYMES; MUTATION OR GENETIC ENGINEERING; ORGANIC CHEMISTRY; PEPTIDES; PHOSPHATIDE COMPOSITIONS FOR FOODSTUFFS; PREPARATIONS FOR MEDICAL, DENTAL, OR TOILET PURPOSES; PRESERVATION OF FOODS OR FOODSTUFFS, IN GENERAL; PROCESSES USING MICROORGANISMS; PROPAGATING, PRESERVING OR MAINTAINING MICROORGANISMS; PROTEIN COMPOSITIONS FOR FOODSTUFFS; SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS ORMEDICINAL PREPARATIONS; SPIRITS; THEIR PREPARATION OR TREATMENT, e.g. COOKING, MODIFICATION OFNUTRITIVE QUALITIES, PHYSICAL TREATMENT; THEIR TREATMENT, NOT COVERED BY OTHER CLASSES; VINEGAR; WINE; WORKING-UP PROTEINS FOR FOODSTUFFS

The invention relates to Enterococcus faecalis bacteria which can produce bioactive peptides, such as peptides with angiotensin converting enzyme inhibitor activity and/or antihypertensive activity. The aforementioned bacteria can be used to ferment a substrate comprising one or more proteins, peptides or fragments thereof which contain the amino acid sequence of said bioactive peptides. Moreover, the above-mentioned bacteria and bioactive peptides can be used in the pharmaceutical and food industries for the preparation of pharmaceutical compositions or functional food products. Péptidos bioactivos y derivados, procedimiento de producción, cepas de enterococcus faecalis productoras de dichos péptidos bioactivos y sus aplicaciones. Se describen unos péptidos bioactivos, en particular, péptidos con actividad inhibidora de la enzima convertidora de la angiotensina y/o con actividad antihipertensiva in vivo, los cuales pueden obtenerse por fermentación de un sustrato que comprende una o más proteínas, péptidos o fragmentos de los mismos que contienen la secuencia de aminoácidos de dichos péptidos bioactivos con la bacteria Enterococcus faecalis. Dicha bacteria y dichos péptidos bioactivos pueden ser utilizados en la industria farmacéutica y alimentaria, en la elaboración de composiciones farmacéuticas, productos alimentarios, productos alimentarios funcionales y suplementos alimentarios.