GENES GAG DEL VIH SINTETICOS

• Main Authors: SHIVER, JOHN, W., JR, DAVIES, MARY-ELLEN, M, FREED, DANIEL, C, LIU, MARGARET, A, PERRY, HELEN, C
• Format: Patent
• Language: Spanish
• Published: 16.05.2007
• Subjects: BEER; BIOCHEMISTRY; CHEMISTRY; COMPOSITIONS THEREOF; CULTURE MEDIA; ENZYMOLOGY; HUMAN NECESSITIES; HYGIENE; MEDICAL OR VETERINARY SCIENCE; METALLURGY; MICROBIOLOGY; MICROORGANISMS OR ENZYMES; MUTATION OR GENETIC ENGINEERING; ORGANIC CHEMISTRY; PEPTIDES; PREPARATIONS FOR MEDICAL, DENTAL, OR TOILET PURPOSES; PROCESSES USING MICROORGANISMS; PROPAGATING, PRESERVING OR MAINTAINING MICROORGANISMS; SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS ORMEDICINAL PREPARATIONS; SPIRITS; VINEGAR; WINE

Se proporcionan moléculas de ADN sintéticas que codifican del gag VIH y modificaciones de gag VIH. Los codones de las moléculas sintéticas son los preferidos por la célula huésped estudiada. Las moléculas sintéticas se pueden usar como una vacuna polinucleotídica que proporciona una inmunoprofilaxis efectiva contra la infección por VIH mediante la estimulación de un anticuerpo neutralizante y la inmunidad por mediación celular. Synthetic DNA molecules encoding HIV gag and modifications of HIV gag are provided. The codons of the synthetic molecules are codons preferred by the projected host cell. The synthetic molecules may be used as a polynucleotide vaccine which provides effective immunoprophylaxis against HIV infection through stimulation of neutralizing antibody and cell-mediated immunity.