2"-OXO-VORUSCHARINA Y DERIVADOS DE LA MISMA

• Main Authors: DEWELLE, JANIQUE, VAN QUAQUEBEKE, ERIC, GUISSOU, PIERRE, NACOULMA, ODILE, GERMAINE, BRAEKMAN, JEAN-CLAUDE, SIMON, GENTIANE
• Format: Patent
• Language: Spanish
• Published: 16.02.2007
• Subjects: ACYCLIC, CARBOCYCLIC OR HETEROCYCLIC COMPOUNDS CONTAININGELEMENTS OTHER THAN CARBON, HYDROGEN, HALOGEN, OXYGEN, NITROGEN,SULFUR, SELENIUM OR TELLURIUM; CHEMISTRY; HETEROCYCLIC COMPOUNDS; HUMAN NECESSITIES; HYGIENE; MEDICAL OR VETERINARY SCIENCE; METALLURGY; ORGANIC CHEMISTRY; PREPARATIONS FOR MEDICAL, DENTAL, OR TOILET PURPOSES; SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS ORMEDICINAL PREPARATIONS

Un compuesto de la fórmula I o una sal farmacéuticamente aceptable del mismo, (Ver fórmula) en la que R1 se selecciona del grupo que comprende hidrógeno, alquilo, alquenilo, alquinilo, alquiloxi, alquiloxialquilo, alquiltioalquilo, alquiloxicarbonilo, alquiltiocarbonilo, alcanoilo, cicloalquilalquilo, cicloalquilcarbonilo, cicloalquilalcanoilo, cicloalquiltiocarbonilo, cicloalquilalcoxicarbonilo, cicloalquilalcoxitiocarbonilo, cicloalquiltioalquilo, alquilcarboniloxialquilo, arilcarboniloxialquilo, cicloalquilcarboniloxialquilo, sililoxialquilo, aralquilo, arilalquenilo, arilcarbonilo, ariloxicarbonilo, ariltiocarbonilo, aralcoxicarbonilo, arilalquiltiocarbonilo, ariloxialquilo, ariltioalquilo, haloalquilo, hidroxialquilo, aralcanoilo, aroilo, ariloxicarbonilalquilo, ariloxialcanoilo, carboxilo, formilo, alquenilcarbonilo, alquinilcarbonilo, Het1, Het1alquilo, Het1oxialquilo, Het1arilo, Het1aralquilo, Het1cicloalquilo, Het1carbonilo, Het1alcoxicarbonilo, Het1alquiltiocarbonilo, Het1oxicarbonilo, Het1tiocarbonilo, Het1alcanoilo, Het1aralcanoilo, Het1ariloxialquilo, Het1alquiloxialquilo, Het1ariltioalquilo, Het1ariloxicarbonilo, Het1aralcoxicarbonilo, Het1aroilo, Het1oxialquilcarbonilo, Het1alquiloxialquilcarbonilo, Het1ariloxialquilcarbonilo, Het1carboniloxialquilo, Het1alquilcarboniloxialquilo, Het1aralquilcarboniloxialquilo, Het2alquilo; Het2oxialquilo, Het2alquiloxialquilo, Het2aralquilo, Het2carbonilo, Het2oxicarbonilo, Het2tiocarbonilo, Het2alcanoilo, Het2alquiltiocarbonilo, Het2alcoxicarbonilo, Het2aralcanoilo, Het2aralcoxicarbonilo, Het2ariloxicarbonilo, Het2aroilo, Het2ariloxialquilo, Het2ariltioalquilo, Het2oxialquilcarbonilo, Het2alquiloxialquilcarbonilo, Het2ariloxialquilcarbonilo, Het2carboniloxialquilo, Het2alquilcarboniloxialquilo, Het2aralquilcarboniloxialquilo, ciano, aminocarbonilo, aminoalcanoilo, aminoalquilo, CR6=NR7 o CR6=N(OR7), con R6 y R7 siendo independientemente seleccionados del grupo que comprende hidrógeno, hidroxilo, alquilo, arilo, Het1, Het1alquilo, Het1arilo, alquenilo, alquinilo, aminoalquilo, aminoarilo, aquilcarbonilamino, arilcarbonilamino, alquiltiocarbonilamino y ariltiocarbonilamino. 2'' oxo-voruscharin compound and derivatives thereof are disclosed as well as pharmaceutical compositions which include 2'' oxo-voruscharin compound or derivatives thereof. The disclosed 2'' oxo-voruscharin compound and its derivatives are useful for cancer treatment. Methods of treating cancer using the disclosed compounds are also disclosed.