PEPTIDOS LINEALES ANTIMICROBIANOS

• Main Authors: MONTESINOS SEGUI EMILI, BARDAJI RODRIGUEZ EDUARD, PLANAS GRABULEDA MARTA, FERRE MALAGON RAFAEL, FELIU SOLEY LIDIA, BADOSA ROMANO ESTHER
• Format: Patent
• Language: Spanish
• Published: 01.11.2007
• Subjects: AGRICULTURE; ANIMAL HUSBANDRY; BIOCIDES, e.g. AS DISINFECTANTS, AS PESTICIDES, AS HERBICIDES; CHEMISTRY; FISHING; FORESTRY; HUMAN NECESSITIES; HUNTING; HYGIENE; MEDICAL OR VETERINARY SCIENCE; METALLURGY; ORGANIC CHEMISTRY; PEPTIDES; PEST REPELLANTS OR ATTRACTANTS; PLANT GROWTH REGULATORS; PREPARATIONS FOR MEDICAL, DENTAL, OR TOILET PURPOSES; PRESERVATION OF BODIES OF HUMANS OR ANIMALS OR PLANTS OR PARTSTHEREOF; SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS ORMEDICINAL PREPARATIONS; TRAPPING

La presente invención se refiere a nuevos péptidos lineales que presentan actividad antimicrobiana. Dichos péptidos están formados por 11 aminoácidos, y tienen el grupo amino del aminoácido que constituye el extremo N-terminal sin derivatizar o funcionalizado con el grupo acetilo, p-toluensulfonilo, bencilo o benzoilo. El aminoácido que constituye el extremo C-terminal de dichos péptidos está en forma de carboxamida. La invención describe la síntesis y la utilización de los mencionados péptidos como agentes antimicrobianos frente a bacterias patógenas para plantas. También se refiere a composiciones que comprenden dichos péptidos y un agente auxiliar, y a un método para prevenir y tratar infecciones y enfermedades de plantas causadas por bacterias patógenas. The linear peptides comprises eleven amino acids. The amino group of the amino acid comprises N-terminal end in a non-derived form or is functionalized with an acetyl group, p-toluene sulphonyl, benzyl or benzoyl. The amino acid comprising the C-terminal end is in carboxamide form. The linear peptides have general formula X 1-X 2-Lys-Leu-Phe-Lys-Lys-Ile-Leu-Lys-X 3-Leu-NH 2. X 1hydrogen, acetyl, p-toluene sulphonyl, benzyl, benzoyl; X 2lysine, tyrosine, leucine, phenylalanine, or tryptophan; X 3lysine, tyrosine, valine, phenylalanine, or tryptophan Independent claims are also included for the following: (1) a plant health composition with a peptide and auxiliary agent (2) a method for preventing and treating plant infections and diseases caused by bacteria. ACTIVITY : Antimicrobial. MECHANISM OF ACTION : None given.