PROTEINA Y PEPTIDOS ALERGENICOS DE CASPA DE PERRO Y SUS USOS

• Main Authors: BRAUER, ANDREW W, BIZINKAUSKAS, CHRISTINE B, MORGENSTERN, JAY P, KONIECZNY, ANDRZEJ
• Format: Patent
• Language: Spanish
• Published: 01.11.2006
• Edition: 4
• Subjects: BEER; BIOCHEMISTRY; CHEMISTRY; COMPOSITIONS THEREOF; CULTURE MEDIA; ENZYMOLOGY; FERMENTATION OR ENZYME-USING PROCESSES TO SYNTHESISE A DESIREDCHEMICAL COMPOUND OR COMPOSITION OR TO SEPARATE OPTICAL ISOMERSFROM A RACEMIC MIXTURE; HUMAN NECESSITIES; HYGIENE; INVESTIGATING OR ANALYSING MATERIALS BY DETERMINING THEIRCHEMICAL OR PHYSICAL PROPERTIES; MEASURING; MEDICAL OR VETERINARY SCIENCE; METALLURGY; MICROBIOLOGY; MICROORGANISMS OR ENZYMES; MUTATION OR GENETIC ENGINEERING; ORGANIC CHEMISTRY; PEPTIDES; PHYSICS; PREPARATIONS FOR MEDICAL, DENTAL, OR TOILET PURPOSES; PROCESSES USING MICROORGANISMS; PROPAGATING, PRESERVING OR MAINTAINING MICROORGANISMS; SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS ORMEDICINAL PREPARATIONS; SPIRITS; TESTING; VINEGAR; WINE

SE HAN DESCUBIERTO ACIDOS NUCLEICOS AISLADOS PORTADORES DE ALERGENOS DEL CANIS FAMILIARIS, CAN F I O CAN F II. TAMBIEN SE DESCRIBE UN CDNA PORTADOR DE UN PEPTIDO QUE TIENE UNA ACTIVIDAD DEL CAN F I Y UN PESO MOLECULAR PREDECIDO DE ALREDEDOR DE 19,200 DALTONES. TAMBIEN SE DESCRIBE UN CDNA PORTADOR DE UN PEPTIDO QUE TIENE UNA ACTIVIDAD DEL CAN F II Y UN PESO MOLECULAR PREDECIDO DE ALREDEDOR DE 18,200 DALTONES. LOS ACIDOS NUCLEICOS PUEDEN SER USADOS COMO SONDAS PARA DETECTAR LA PRESENCIA DE ACIDOS NUCLEICOS DE CAN F O CAN F II EN UNA MUESTRA O PARA LA PRODUCCION RECOMBINANTE DE PEPTIDOS QUE TENGAN ACTIVIDAD DE CAN F I O CAN F II. PEPTIDOS QUE TENGAN UNA ACTIVIDAD DE CAN F I O CAN F II PUEDEN SER USADOS EN COMPOSICIONES INDICADAS PARA LA ADMINISTRACION FARMACEUTICA O METODOS PARA DIAGNOSTICAR LA SENSIBILIDAD A LA CASPA CANINA. Nucleic acids encoding an allergen of Canis familiaris, Can f II, are disclosed. The nucleic acids can be used as probes to detect the presence of Can f II nucleic acid in a sample or for the recombinant production of peptides having a Can f II activity. Peptides having a Can f II activity can be used in compositions suitable for pharmaceutical administration or methods of diagnosing sensitivity to dog dander.