ISOQUINOLINE DERIVATIVES AS CALPAIN INHIBITORS

• Main Authors: HERRADON GARCIA BERNANDO, CHICHARRO MARTIN ROBERTO, ARAN REDO VICENTE, ALONSO GINER MERCEDES
• Format: Patent
• Language: English; Spanish
• Published: 01.07.2006
• Subjects: CHEMISTRY; HETEROCYCLIC COMPOUNDS; HUMAN NECESSITIES; HYGIENE; MEDICAL OR VETERINARY SCIENCE; METALLURGY; ORGANIC CHEMISTRY; PREPARATIONS FOR MEDICAL, DENTAL, OR TOILET PURPOSES; SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS ORMEDICINAL PREPARATIONS

The invention relates to derivative compounds of partially-reduced isoquinoline with substitution of a sec -butyl group at position 3 with calpain inhibitor activity. The inventive compound comprises an ester or amide derived from (3- sec -butyl-1-oxo-2,3-dihydro-1 H -isoquinolin-4-yliden)-acetic acid and (3- sec -butyl-1-thioxo-2,3-dihydro-1 H -isoquinolin-4-yliden)-acetic acid. Compounds having formula I or II can be used in the preventive or therapeutic treatment of a degenerative disease. Derivados de isoquinolina como inhibidores de calpaina. La presente invención se refiere a compuestos derivados de isoquinolina parcialmente reducida con sustitución de un grupo sec-butilo en posición 3 con actividad como inhibidores de calpaina. Un compuesto de la presente invención es un éster o amida derivada del ácido (3-sec-butil-1-oxo-2,3-dihidro-1 H-isoquinolin-4-iliden)-acético y de ácido (3-sec-butil-1-tioxo-2,3-dihidro-1H-isoquinolin-4-iliden)-acético. Los compuestos de fórmula I o II tienen aplicación en el tratamiento preventivo o terapéutico de una enfermedad degenerativa.