PARTICULAS DE INHALACION

• Main Authors: JOKINIEMI, JORMA, WATANABE, WIWIK, AHONEN, PETRI, JARVINEN, RAOUL, KAUPPINEN, ESKO, BROWN, DAVID
• Format: Patent
• Language: Spanish
• Published: 01.05.2006
• Edition: 4
• Subjects: CHEMICAL ASPECTS OF BANDAGES, DRESSINGS, ABSORBENT PADS, ORSURGICAL ARTICLES; DISINFECTION, STERILISATION, OR DEODORISATION OF AIR; HUMAN NECESSITIES; HYGIENE; MAKING GRANULES OR PREFORMS; MATERIALS FOR BANDAGES, DRESSINGS, ABSORBENT PADS, OR SURGICALARTICLES; MEDICAL OR VETERINARY SCIENCE; METHODS OR APPARATUS FOR STERILISING MATERIALS OR OBJECTS INGENERAL; PERFORMING OPERATIONS; PREPARATION OR PRETREATMENT OF THE MATERIAL TO BESHAPED; PREPARATIONS FOR MEDICAL, DENTAL, OR TOILET PURPOSES; RECOVERY OF PLASTICS OR OTHER CONSTITUENTS OF WASTE MATERIALCONTAINING PLASTICS; SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS ORMEDICINAL PREPARATIONS; TRANSPORTING; WORKING OF PLASTICS; WORKING OF SUBSTANCES IN A PLASTIC STATE, IN GENERAL

Método para preparar partículas adecuadas para la administración pulmonar de fármacos, que comprende las etapas de: proporcionar una reserva de alimentación líquida que comprende uno o varios principios activos; atomizar la reserva de alimentación líquida para crear gotitas; suspender dichas gotitas en un gas vehículo; hacer pasar dicho gas vehículo y las gotitas suspendidas en el mismo a través de un reactor de flujo de tubo calentado con tiempo de permanencia e historial de temperatura predeterminados; y recoger las partículas producidas. A method for preparing particles suitable for pulmonary drug delivery by inhalation, and inhalation compositions comprising such particles are provided. The method comprises providing a liquid feed stock comprising one or several active agents, atomising the liquid feed stock, suspending the droplets in a carrier gas, and passing the carrier gas and droplets through a heated tube flow reactor under predetermined residence time and temperature history, and collecting the particles produced. Fine uniform crystalline spherical uncharged particles with narrow aerodynamic particle size distribution between about 1 to 5 mum and rough surfaces, are obtained. The particles show improved dispersibility and stability.