PREPARACIONES DE HIALURONIDASA PARA EL TRATAMIENTO DE LA SANGRE HEMORRAGICA INTRAVITREA

• Main Authors: ARAGON, GABRIEL A. C, NESBURN, ANTHONY B, KARAGEOZIAN, HAMPAR L, FLORES, JOSE L. G, KARAGEOZIAN, VICKEN H, KENNEY, MARIA C
• Format: Patent
• Language: Spanish
• Published: 01.01.2006
• Edition: 4
• Subjects: HUMAN NECESSITIES; HYGIENE; MEDICAL OR VETERINARY SCIENCE; PREPARATIONS FOR MEDICAL, DENTAL, OR TOILET PURPOSES; SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS ORMEDICINAL PREPARATIONS

PREPARACION DE HIALURONIDASA SIN TIMEROSAL EN LA QUE LA ENZIMA HIALURONIDASA PREFERIDA NO TIENE FRACCIONES MOLECULARES INFERIORES A 40.000 PM, DE 60-70.000 PM, Y MAYORES DE 100.000 PM. SE DESCRIBE TAMBIEN UN METODO PARA ACELERAR LA ELIMINACION DE SANGRE HEMORRAGICA DEL HUMOR VITREO DEL OJO; ESTE METODO COMPRENDE LA ETAPA DE PONER EN CONTACTO AL MENOS UNA ENZIMA QUE ELIMINA LA HEMORRAGIA (P.EJ., UNA BE GLUCURONIDASA, MATRIZ DE METALOPROTEINASA, CONDROTOINASA, SULFATASA DE CONDROITINA O PROTEINCINASA) CON EL HUMOR VITREO EN UNA CANTIDAD QUE ES EFICAZ PARA ACELERAR LA ELIMINACION DE LA SANGRE EN EL HUMOR VITREO A thimerosal-free hyaluronidase preparation wherein the preferred hyaluronidase enzyme is devoid of molecular weight fractions below 40,000 MW, between 60-70,000 MW and above 100,000 MW. Also disclosed is a method for accelerating the clearance of hemorrhagic blood from the vitreous humor of the eye, said method comprising the step of contacting at least one hemorrhage-clearing enzyme (e.g., a beta-glucuronidase, matrix metalloproteinase, chondroitinase, chondroitin sulfatase or protein kinase) with the vitreous humor in an amount which is effective to cause accelerated clearance of blood therefrom.