2-[4- (2-HYDROXYMETHYL-PHENYLAMINO)-PIPERIDIN-1-YL] - N-(9H-CARBAZOL-3-YL) - ACETAMIDE DERIVATIVES AND RELATED COMPOUNDS AS NEUROPEPTIDE Y5 (NPY5) LIGANDS FOR THE TREATMENT OF OBESITY

• Main Authors: DORDAL ZUERAS ALBERTO, FISAS ESCASANY MARIA ANGELES, TORRENS JOVER ANTONI, MAS PRIO JOSEP
• Format: Patent
• Language: English; Spanish
• Published: 01.02.2005
• Edition: 7
• Subjects: CHEMISTRY; HETEROCYCLIC COMPOUNDS; HUMAN NECESSITIES; HYGIENE; MEDICAL OR VETERINARY SCIENCE; METALLURGY; ORGANIC CHEMISTRY; SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS ORMEDICINAL PREPARATIONS

It was an object of the present invention to provide novel compounds that are suitable in particular as active substances in medicaments, preferably in medicaments for the regulation of neuropeptide Y receptors, particularly preferably of neuropeptide Y5 (NPY5) receptor, for the regulation of food ingestion (food intake), preferably for the prophylaxis and/or treatment of disorders of food ingestion, such as obesity., anorexia, cachexia, bulimia or type II (non insulin dependent) diabetes, for the prophylaxis and/or treatment of disorders of the peripheral nervous system, disorders of the central nervous system, anxiety, depression, cognitive disorders, preferably memory disorders, cardiovascular diseases, pain, epilepsy, arthritis, hypertensive syndrom, inflammatory diseases, immune diseases and other NPY5 mediated disorders in animals and mammals, including man. Said object was achieved by providing 1,4-disubstituted piperidine compounds of general formula (1) wherein the substituents are defined in claim 1. Compuestos piperidínicos 1,4-disustituidos, su preparación y su uso como medicamentos. La presente invención se refiere a compuestos piperidínicos 1,4-disustituidos de fórmula general (1), a los métodos para su preparación, a los medicamentos que contienen estos compuestos, así como a su uso para la preparación de un medicamento para el tratamiento de humanos o animales.