POLIPEPTIDOS DERIVADOS DE LAS PROTEINAS DEL VIRUS DE LA HEPATITIS C

• Main Authors: FUCHS, KLAUS, MOTZ, MANFRED, ROGGENDORF, MICHAEL, SOUTSCHEK, ERWIN
• Format: Patent
• Language: Spanish
• Published: 01.02.2005
• Edition: 7
• Subjects: BEER; BIOCHEMISTRY; CHEMISTRY; COMPOSITIONS OR TEST PAPERS THEREFOR; COMPOSITIONS THEREOF; CONDITION-RESPONSIVE CONTROL IN MICROBIOLOGICAL ORENZYMOLOGICAL PROCESSES; CULTURE MEDIA; DERIVATIVES THEREOF; ENZYMOLOGY; FERMENTATION OR ENZYME-USING PROCESSES TO SYNTHESISE A DESIREDCHEMICAL COMPOUND OR COMPOSITION OR TO SEPARATE OPTICAL ISOMERSFROM A RACEMIC MIXTURE; HUMAN NECESSITIES; HYGIENE; INVESTIGATING OR ANALYSING MATERIALS BY DETERMINING THEIRCHEMICAL OR PHYSICAL PROPERTIES; MEASURING; MEASURING OR TESTING PROCESSES INVOLVING ENZYMES, NUCLEICACIDS OR MICROORGANISMS; MEDICAL OR VETERINARY SCIENCE; METALLURGY; MICROBIOLOGY; MICROORGANISMS OR ENZYMES; MUTATION OR GENETIC ENGINEERING; NUCLEIC ACIDS; NUCLEOSIDES; NUCLEOTIDES; ORGANIC CHEMISTRY; PEPTIDES; PHYSICS; PREPARATIONS FOR MEDICAL, DENTAL, OR TOILET PURPOSES; PROCESSES OF PREPARING SUCH COMPOSITIONS; PROCESSES USING MICROORGANISMS; PROPAGATING, PRESERVING OR MAINTAINING MICROORGANISMS; SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS ORMEDICINAL PREPARATIONS; SPIRITS; SUGARS; TESTING; VINEGAR; WINE

SE OFRECE LA CLONACION Y SECUENCIACION DE POLIPEPTIDOS DIFERENTES A PARTIR DEL GENONA DE UNOS VIRUS DE LA HEPATITIS C. LOS POLIPEPTIDOS, QUE SE OBTIENEN COMO UNA PROTEINA NO FUSIONADA Y CON BUEN RENDIMIENTO. LOS POLIPEPETIDOS QUE PROCEDEN DE LA ESTRUCTURA BASICA DE LAS PROTEINAS, SE DILUYEN BAJO CONDICIONES FISIOLOGICAS. LOS POLIPEPTIDOS NO PRESENTAN NINGUNA FRACCION DE PROTEINA AFIN Y SE EMPLEAN COMO VACUNAS Y EN PRUEBAS DE ENSAYOS. PCT No. PCT/DE91/01020 Sec. 371 Date Oct. 15, 1993 Sec. 102(e) Date Oct. 15, 1993 PCT Filed Dec. 20, 1991 PCT Pub. No. WO92/11370 PCT Pub. Date Jul. 9, 1992The cloning and sequencing of different polypeptides from the genome of a hepatitis C virus is disclosed. The polypeptides are prepared as non-fusion proteins in good yield. The polypeptide originating from the structure protein (core) is soluble under physiological conditions. Since the polypeptides have no foreign protein portions, they are preferably used in test kits and as vaccine.