METODOS PARA MEJORAR LA ACTIVIDAD BIOLOGICA DE QUIMIOCINAS

• Main Authors: BALCAREK, JOANNA MARIA, PELUS, LOUIS M, KING, ANDREW GARRISON, BHATNAGAR, PRADIP KUMAR
• Format: Patent
• Language: Spanish
• Published: 01.07.2004
• Edition: 7
• Subjects: BEER; BIOCHEMISTRY; CHEMISTRY; COMPOSITIONS THEREOF; CULTURE MEDIA; ENZYMOLOGY; FERMENTATION OR ENZYME-USING PROCESSES TO SYNTHESISE A DESIREDCHEMICAL COMPOUND OR COMPOSITION OR TO SEPARATE OPTICAL ISOMERSFROM A RACEMIC MIXTURE; HUMAN NECESSITIES; HYGIENE; INVESTIGATING OR ANALYSING MATERIALS BY DETERMINING THEIRCHEMICAL OR PHYSICAL PROPERTIES; MEASURING; MEDICAL OR VETERINARY SCIENCE; METALLURGY; MICROBIOLOGY; MICROORGANISMS OR ENZYMES; MUTATION OR GENETIC ENGINEERING; ORGANIC CHEMISTRY; PEPTIDES; PHYSICS; PREPARATIONS FOR MEDICAL, DENTAL, OR TOILET PURPOSES; PROCESSES USING MICROORGANISMS; PROPAGATING, PRESERVING OR MAINTAINING MICROORGANISMS; SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS ORMEDICINAL PREPARATIONS; SPIRITS; TESTING; VINEGAR; WINE

LA PRESENTE INVENCION PROPORCIONA UN METODO PARA INCREMENTAR LA ACTIVIDAD BIOLOGICA DE PROTEINAS KC, GRO-{AL}, GRO-{BE} Y GRO{GA}, PROTEINAS TRUNCADAS Y MODIFICADAS CARACTERIZADAS POR TENER ACTIVIDAD BIOLOGICA DE AL MENOS 1 LOG MEJOR QUE LA PROTEINA DE LONGITUD COMPLETA, Y COMPOSICIONES FARMACEUTICAS QUE CONTIENEN LA MISMA. The present invention provides antibodies capable of binding to truncated and modified chemokines characterized by having biological activity at least 1 log better than the full-length chemokine, and relates to methods involving such antibodies.