FORMULACIONES PARA LA ADMINISTRACION DE PROTEINAS OSTEOGENICAS

• Main Authors: SCHRIER, JAY A, NORTHEY, RICHARD P., JR, YIM, KALVIN W. K, HUBERTY, MICHAEL C, SMITH, JENNIFER L, KENLEY, RICHARD A
• Format: Patent
• Language: Spanish
• Published: 16.12.2003
• Edition: 7
• Subjects: CHEMICAL ASPECTS OF BANDAGES, DRESSINGS, ABSORBENT PADS, ORSURGICAL ARTICLES; DISINFECTION, STERILISATION, OR DEODORISATION OF AIR; HUMAN NECESSITIES; HYGIENE; MATERIALS FOR BANDAGES, DRESSINGS, ABSORBENT PADS, OR SURGICALARTICLES; MEDICAL OR VETERINARY SCIENCE; METHODS OR APPARATUS FOR STERILISING MATERIALS OR OBJECTS INGENERAL; PREPARATIONS FOR MEDICAL, DENTAL, OR TOILET PURPOSES; SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS ORMEDICINAL PREPARATIONS

SE DESCRIBE UNA COMPOSICION QUE COMPRENDE UNA MEZCLA FARMACEUTICAMENTE ACEPTABLE DE UNA PROTEINA OSTEOGENETICA; UNA MATRIZ DE POLIMERO PARTICULADO POROSO; UNA CANTIDAD DE SEGREGACION DE PROTEINA OSTEOGENETICA DE COAGULOS SANGUINEO; Y UNA SUSTANCIA QUE CONTENGA HEMIHIDRATO DE SULFATO CALCICO. TAMBIEN SE DESCRIBEN FORMULACIONES DE PROTEINAS MORFOGENETICAS OSEAS CON SOLUBILIDAD MEJORADA Y/O CARACTERISTICAS DE ESTABILIDAD. A composition is disclosed comprising a pharmaceutically acceptable admixture of an osteogenic protein; a porous particulate polymer matrix; an osteogenic protein-sequestering amount of blood clot; and a calcium sulfate hemihydrate-containing substance. Also disclosed are formulations of bone morphogenetic proteins with improved solubility and/or stability characteristics.