FORMULACIONES PARA LA ADMINISTRACION DE PROTEINAS OSTEOGENICAS

SE DESCRIBE UNA COMPOSICION QUE COMPRENDE UNA MEZCLA FARMACEUTICAMENTE ACEPTABLE DE UNA PROTEINA OSTEOGENETICA; UNA MATRIZ DE POLIMERO PARTICULADO POROSO; UNA CANTIDAD DE SEGREGACION DE PROTEINA OSTEOGENETICA DE COAGULOS SANGUINEO; Y UNA SUSTANCIA QUE CONTENGA HEMIHIDRATO DE SULFATO CALCICO. TAMBIEN...

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Bibliographic Details
Main Authors SCHRIER, JAY A, NORTHEY, RICHARD P., JR, YIM, KALVIN W. K, HUBERTY, MICHAEL C, SMITH, JENNIFER L, KENLEY, RICHARD A
Format Patent
LanguageSpanish
Published 16.12.2003
Edition7
Subjects
CHEMICAL ASPECTS OF BANDAGES, DRESSINGS, ABSORBENT PADS, ORSURGICAL ARTICLES
DISINFECTION, STERILISATION, OR DEODORISATION OF AIR
HUMAN NECESSITIES
HYGIENE
MATERIALS FOR BANDAGES, DRESSINGS, ABSORBENT PADS, OR SURGICALARTICLES
MEDICAL OR VETERINARY SCIENCE
METHODS OR APPARATUS FOR STERILISING MATERIALS OR OBJECTS INGENERAL
PREPARATIONS FOR MEDICAL, DENTAL, OR TOILET PURPOSES
SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS ORMEDICINAL PREPARATIONS
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Summary:SE DESCRIBE UNA COMPOSICION QUE COMPRENDE UNA MEZCLA FARMACEUTICAMENTE ACEPTABLE DE UNA PROTEINA OSTEOGENETICA; UNA MATRIZ DE POLIMERO PARTICULADO POROSO; UNA CANTIDAD DE SEGREGACION DE PROTEINA OSTEOGENETICA DE COAGULOS SANGUINEO; Y UNA SUSTANCIA QUE CONTENGA HEMIHIDRATO DE SULFATO CALCICO. TAMBIEN SE DESCRIBEN FORMULACIONES DE PROTEINAS MORFOGENETICAS OSEAS CON SOLUBILIDAD MEJORADA Y/O CARACTERISTICAS DE ESTABILIDAD. A composition is disclosed comprising a pharmaceutically acceptable admixture of an osteogenic protein; a porous particulate polymer matrix; an osteogenic protein-sequestering amount of blood clot; and a calcium sulfate hemihydrate-containing substance. Also disclosed are formulations of bone morphogenetic proteins with improved solubility and/or stability characteristics.
Bibliography:Application Number: ES19940930410T