COMPUESTOS DE LACTONA MACROCICLICA Y SU PROCEDIMIENTO DE PRODUCCION

• Main Authors: INAGAKI, T, YAMAUCHI, Y, KOJIMA, N.-PFIZER PHARM. INC, KOJIMA, Y.-PFIZER PHAR. INC, NISHIDA, H
• Format: Patent
• Language: Spanish
• Published: 16.11.2003
• Edition: 7
• Subjects: BEER; BIOCHEMISTRY; CHEMISTRY; CONTROL OR REGULATING SYSTEMS IN GENERAL; CONTROLLING; CONVEYING; DERIVATIVES THEREOF; ENZYMOLOGY; FERMENTATION OR ENZYME-USING PROCESSES TO SYNTHESISE A DESIREDCHEMICAL COMPOUND OR COMPOSITION OR TO SEPARATE OPTICAL ISOMERSFROM A RACEMIC MIXTURE; FUNCTIONAL ELEMENTS OF SUCH SYSTEMS; HANDLING THIN OR FILAMENTARY MATERIAL; HETEROCYCLIC COMPOUNDS; HUMAN NECESSITIES; HYGIENE; MACHINES, APPARATUS OR DEVICES FOR, OR METHODS OF, PACKAGINGARTICLES OR MATERIALS; MEASURING; MEASURING ANGLES; MEASURING AREAS; MEASURING IRREGULARITIES OF SURFACES OR CONTOURS; MEASURING LENGTH, THICKNESS OR SIMILAR LINEARDIMENSIONS; MEDICAL OR VETERINARY SCIENCE; METALLURGY; MICROBIOLOGY; MONITORING OR TESTING ARRANGEMENTS FOR SUCH SYSTEMS ORELEMENTS; MUTATION OR GENETIC ENGINEERING; NUCLEIC ACIDS; NUCLEOSIDES; NUCLEOTIDES; ORGANIC CHEMISTRY; PACKING; PERFORMING OPERATIONS; PHYSICS; PNEUMATIC TUBE CONVEYORS; PREPARATIONS FOR MEDICAL, DENTAL, OR TOILET PURPOSES; PROCESSES USING MICROORGANISMS; REGULATING; SHOP CONVEYOR SYSTEMS; SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS ORMEDICINAL PREPARATIONS; SPIRITS; STORING; SUGARS; SYSTEMS FOR CONTROLLING OR REGULATING NON-ELECTRIC VARIABLES; TESTING; TRANSPORT OR STORAGE DEVICES, e.g. CONVEYORS FOR LOADING ORTIPPING; TRANSPORTING; UNPACKING; VINEGAR; WINE

ESTA INVENCION DESCRIBE UN PROCEDIMIENTO PARA PRODUCIR UN COMPUESTO DE LACTONA MACROCICLICA QUE INCLUYE CULTIVAR ACTINOPLANES SP. FERM BP - 3832, EN PRESENCIA DE L - PROLINA, L HIDROXIPROLINA O ACIDO L - NIPECOTICO, Y DESPUES AISLAR UN COMPUESTO DE LACTONA MACROCICLICA A PARTIR DEL CALDO DE FERMENTACION. LOS COMPUESTOS PRODUCIDOS MEDIANTE ESTE PROCEDIMIENTO INCLUYEN UN COMPUESTO DE FORMULA (I). LA PRESENTE INVENCION TAMBIEN TRATA DE UNA COMPOSICION FARMACEUTICA QUE INCLUYE EL MISMO, QUE RESULTA UTIL COMO AGENTE INMUNOSUPRESOR, ANTIMICOTICO, ANTITUMORAL O SIMILARES. This invention provides a process for producing a macrocyclic lactone compound, which comprises cultivating Actinoplanes sp. FERM BP-3832, in the presence of L-proline, L-hydroxyproline or L-nipecotic acid, and then isolating a macrocylic lactone compound from the fermentation broth. The compounds produced by this process include a compound of the following formula:The present invention also relates to a pharmaceutical composition comprising the same, which is useful as immunosuppressive, antimycotic, antitumor agent or the like.