PROCEDIMIENTO Y COMPUESTOS INTERMEDIOS PARA LA PREPARACION DE BENCENSULFONATO DE AMLODIPINA

• Main Authors: SIMIG, GYULA, BOZSING, DANIEL, KOVANYI, GYORGYI, LAX, BLASKO, GABOR, KRASZNAI, GYORGY, TOMPE, PETER
• Format: Patent
• Language: Spanish
• Published: 16.11.2002
• Edition: 7

EL OBJETO DE LA PRESENTE INVENCION ES UN PROCESO PARA LA PREPARACION DE LA SAL DEL ACIDO 3 - [ETIL] - 5 - [METIL] - 2 [2'' - (AMINOETOXI) - METIL] - 4 - [2''' - (CLORO) - FENIL] - 6 [METIL] - 1,4 - DI - [HIDRO] - PIRIDIN - 3,5 - DI - [CARBOXILATO] - BENCENSULFONICO DE FORMULA I EN LA QUE EL YODURO DE 3 [ETIL] - 5 - [METIL] - 2 - [2'' - (IL) ETOXI - METIL] - 4 - [2''' - (CLORO) - FENIL] - 6 - [METIL] - 1,4 DI - [HIDRO] - PIRIDIN - 3,5 - DI - [CARBOXILATO] - HEXAMINIO DE FORMULA XI SE HACE REACCIONAR CON ACIDO BENCENSULFONICO DE FORMULA XII. ALGUNAS VARIANTES COMPRENDEN IGUALMENTE REACCIONES PARA PREPARAR INTERMEDIOS QUE LLEVEN AL CITADO PRODUCTO FINAL. UN OBJETO ADICIONAL DE LA INVENCION ES OBTENER LOS PRODUCTOS PARA LA PREPARACION DEL CITADO PRODUCTO FINAL. A subject matter of the invention is a process for preparing 3-ÄethylÜ-5-ÄmethylÜ-2-Ä2'-(aminoethoxy)-methylÜ-4--Ä2''-(chloro)-phen ylÜ-6-ÄmethylÜ-1,4-di-ÄhydroÜ-pyridine-3,5-di-ÄcarboxylateÜ benzenesulfonic acid salt of Formula in which 3-ÄethylÜ-5-ÄmethylÜ-2-Ä2'-(yl)-ethoxy-methylÜ-4-Ä2''-(chloro)-phenylÜ -6-ÄmethylÜ-1,4-di-ÄhydroÜ-pyridine-3,5-di-ÄcarboxylateÜ hexaminium iodide of Formula is reacted with benzenesulfonic acid of Formula Several variants comprise also reactions for preparing intermediates leading to the said end product. A further subject matter of the invention are intermediates for preparing the said end product.