INHIBIDORES DE LA PROTEINA QUINASA C

• Main Authors: JIROUSEK, MICHAEL, ROBERT, GILLIG, JAMES, RONALD
• Format: Patent
• Language: Spanish
• Published: 01.10.2001
• Edition: 7
• Subjects: CHEMISTRY; HETEROCYCLIC COMPOUNDS; HUMAN NECESSITIES; HYGIENE; MEDICAL OR VETERINARY SCIENCE; METALLURGY; ORGANIC CHEMISTRY; PREPARATIONS FOR MEDICAL, DENTAL, OR TOILET PURPOSES; SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS ORMEDICINAL PREPARATIONS

LA PRESENTE INVENCION DESCRIBE COMPOSICIONES QUE SON POTENTES INHIBIDORES SELECTIVOS DE ISOZIMA, DE ISOZIMA BETA-1 Y BETA-2 DE LA PROTEINA CINASA C. ESTAS COMPOSICIONES SON 3,4-DI-[[]3''(()1''SUSTITUIDO())-INDOLIL[]]-1H-PIRROL-2,5-DIONAS, QUE PUEDEN SER DESCRITAS MAS COMUNMENTE COMO 3,4-BIS(()3''-INDOLIL()) MALEIMIDAS. ADEMAS, COMO INHIBIDORES SELECTIVOS DE ISOZIMA DE LAS ISOZIMAS BETA-1 Y BETA-2, LAS COMPOSICIONES SON TERAPEUTICAMENTE UTILES EN EL TRATAMIENTO DE CONDICIONES ASOCIADAS CON DIABETES MELLITUS Y SUS COMPLICACIONES, ASI COMO OTROS ESTADOS DE ENFERMEDADES ASOCIADOS CON UNA ELEVACION DE ESTAS ISOZIMAS. The present invention discloses compounds that are highly isozyme selective protein kinase C beta-1 and beta-2 isozyme inhibitors. The present invention also provides a method of selectively inhibiting protein kinase C isozymes beta-1, and beta-2. As isozyme selective inhibitors of beta-1 and beta-2, the compounds are therapeutically useful in treating conditions associated with diabetes mellitus and its complications, as well as other disease states associated with an elevation of the beta-1 and beta-2 isozyme.