PARCHE QUE CONTIENE DINITRATO DE ISOSORBIDA Y QUE SE PREPARA UTILIZANDO UNA MEZCLA DE ADHESIVOS

• Main Authors: IWATA, MAKOTO, FURUYA, MINORU TEIJIN LIMITED, OHE, MICHISUKE TEYSAN PHARMACEUTICALS CO., LTD, FUJII, TAKAO TEIJIN LIMITED TOKYO RESEARCH CENTER
• Format: Patent
• Language: Spanish
• Published: 16.09.2001
• Edition: 7
• Subjects: HUMAN NECESSITIES; HYGIENE; MEDICAL OR VETERINARY SCIENCE; PREPARATIONS FOR MEDICAL, DENTAL, OR TOILET PURPOSES

LA PRESENTE INVENCION DESCRIBE UN PARCHE QUE CONTIENE ISDN QUE CAUSA UNA INCIDENCIA MINIMA DE RASH CUTANEO Y MUESTRA UNA EXCELENTE ABSORCION PERCUTANEA Y FUERZA ADHESIVA. LA PRESENTE INVENCION DESCRIBE UN PARCHE QUE CONTIENE DINITRATO DE ISOSORBIDE Y CONSTA DE: UNA CAPA ADHESIVA SOBRE UN SOPORTE FLEXIBLE, QUE INCLUYE LA COMPOSICION ADHESIVA FORMADA POR UN ADHESIVO Y DINITRATO DE ISOSORBIDE. EL ADHESIVO TIENE UNA BASE DE SILICONA (A) Y POLIVINIL ACETATO (B) EN UNA RAZON DE PESOS A:B = 85:15 A 15:85 Y UNA RAZON DE PESOS ENTRE EL DINITRATO DE ISOSORBIDE (C) Y LOS ADHESIVOS (A+B) DE (A+B):(C) = 90:10 A 60:40. The present invention provides an ISDN-containing patch that causes minimal occurrence of skin rash and has excellent percutaneous absorption and adhesive strength. The present invention discloses an isosorbide dinitrate-containing patch comprising: an adhesive layer formed on a flexible support, wherein said layer comprises an adhesive composition containing adhesive and isosorbide dinitrate, the adhesive being composed of silicone-based adhesive (A) and polyvinyl acetate-based adhesive (B), their weight ratio being A:B = 85:15 to 15:85, and the weight ratio of isosorbide dinitrate (C) to the adhesives (A+B) being (A+B):C = 90:10 to 60:40.