PROCEDIMIENTO PARA LA PREPARACION DE TRIHIDRATO DEL (2R,3S)-3-TERC-BUTOXICARBONILAMINO-2-HIDROXI-3-FENILPROPIONATO DE 4-ACETOXI-2ALFA-BENZOILOXI-5BETA,20-EPOXI-1,7BETA,10BETA-TRIHIDROXI-9-OXO-TAX-11-EN-13ALFA-ILO

• Main Authors: MANDARD, BERNADETTE, TAILLEPIED, ISABELLE, DOVEZE, JACQUES, FOUQUE, ELIE, AUTHELIN, JEAN-RENE
• Format: Patent
• Language: Spanish
• Published: 16.11.1998
• Edition: 6
• Subjects: CHEMISTRY; HETEROCYCLIC COMPOUNDS; HUMAN NECESSITIES; HYGIENE; MEDICAL OR VETERINARY SCIENCE; METALLURGY; ORGANIC CHEMISTRY; PREPARATIONS FOR MEDICAL, DENTAL, OR TOILET PURPOSES

PROCEDIMIENTO DE PREPARACION DE TRIHIDRATO DE ( 2R, 3S )}TERT-BUTOXICARBONILAMINO-2-HIDROXI-3-FENILPROPIONATO DE 4ACETOXI-2{AL}-BENCOILOXI-5{BE},20-EPOXI-1,7{BE}-TRIHODROXI-9-OXO-TAX-11-EN-13{AL}-ILO POR CRISTALIZACION A PARTIR DE UNA SOLUCION HIDROALCOHOLICA. PCT No. PCT/FR95/00910 Sec. 371 Date Apr. 25, 1997 Sec. 102(e) Date Apr. 25, 1997 PCT Filed Jul. 7, 1995 PCT Pub. No. WO96/01815 PCT Pub. Date Jan. 25, 1996Process for the preparation of 4-acetoxy-2 alpha -benzoyloxy-5 beta ,20-epoxy-1,7 beta , 10 beta -trihydroxy-9-oxo-tax-11-en-13 alpha -yl (2R,3S)-3-tert-butoxycarbonylamino-2-hydroxy-3-phenylpropionate trihydrate, characterized in that the 4-acetoxy-2 alpha -benzoyloxy-5 beta ,20-epoxy-1,7 beta ,10 beta -trihydroxy-9-oxo-tax-11-en-13 alpha -yl (2R,3S)-3-tert-butoxycarbonylamino-2-hydroxy-3-phenylpropionate is crystallized from a mixture of water and an aliphatic alcohol containing 1 to 3 carbon atoms, and then the product obtained is dried under defined conditions of temperature, pressure and humidity.