DETERMINACION DE ACTIVIDADES PLAQUETARIAS

• Main Authors: HEMKER, HENDRIK, C, WAGENVOORD, ROBERT, J
• Format: Patent
• Language: Spanish
• Published: 16.05.1998
• Edition: 6
• Subjects: BEER; BIOCHEMISTRY; CHEMISTRY; COMPOSITIONS OR TEST PAPERS THEREFOR; CONDITION-RESPONSIVE CONTROL IN MICROBIOLOGICAL ORENZYMOLOGICAL PROCESSES; ENZYMOLOGY; INVESTIGATING OR ANALYSING MATERIALS BY DETERMINING THEIRCHEMICAL OR PHYSICAL PROPERTIES; MEASURING; MEASURING OR TESTING PROCESSES INVOLVING ENZYMES, NUCLEICACIDS OR MICROORGANISMS; METALLURGY; MICROBIOLOGY; MUTATION OR GENETIC ENGINEERING; PHYSICS; PROCESSES OF PREPARING SUCH COMPOSITIONS; SPIRITS; TESTING; VINEGAR; WINE

SE PREVEN METODOS PARA MEDIR LA ACTIVIDAD PRO-COAGULANTE DE PLAQUETAS EN LA SANGRE POR MEDIO DE UN ANALISIS CROMOGENICO QUE ES ESPECIFICO PARA FOSFOLIPIDOS PRO-COAGULANTES. ESTOS METODOS INCLUYEN LA DETERMINACION DE LA ACTIVIDAD DE REPOSO Y/O EXCITABILIDAD DE LAS PLAQUETAS, LO QUE DETERMINA EL UMBRAL EN EL QUE LOS FACTORES DE ACTIVACION DE COAGULACION (CIRCULANTES EN SANGRE) SON PELIGROSOS. TAMBIEN SE PREVEN METODOS PARA MEDICAMENTOS DE PROTECCION POR SU EFECTO POTENCIAL INHIBITORIO SOBRE LA ACTIVACION DE PLAQUETAS. Methods are provided for measuring the procoagulant activity of platelets in blood by means of a chromogenic assay which is specific for procoagulant phospholipids. These methods include the determination of the resting activity and/or excitability of platelets, which determines the threshold at which activating clotting factors (circulating in blood) are dangerous. Also methods are provided for screening drugs for their potential inhibitory effect on the activation of platelets.