LIBERACION DE AGENTES

• Main Authors: VERHOEYEN, MARTINE ELISA, BEGGS, THOMAS STEWART, DAVIS, PAUL JAMES
• Format: Patent
• Language: Spanish
• Published: 01.11.1997
• Edition: 6
• Subjects: CHEMISTRY; HUMAN NECESSITIES; HYGIENE; MEDICAL OR VETERINARY SCIENCE; METALLURGY; ORGANIC CHEMISTRY; PEPTIDES; PREPARATIONS FOR MEDICAL, DENTAL, OR TOILET PURPOSES; SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS ORMEDICINAL PREPARATIONS; SPECIFIC USE OF COSMETICS OR SIMILAR TOILETPREPARATIONS

UN FRAGMENTO DE ANTICUERPO CAPAZ DE UNIRSE A UN DETERMINANTE SE PROLONGA MEDIANTE UN PEPTIDO ADICIONAL. EL AGENTE TERAPEUTICO SE ENLAZA A ESTE PEPTIDO O BIEN SE SUMINISTRA MEDIOS PARA REALIZAR ESTA UNION. EL FRAGMENTO DE ANTICUERPO Y POSIBLEMENTE TAMBIEN EL AGENTE TERAPEUTICO SE ENCUENTRAN INCLUIDOS EN UN PRODUCTO DE TAL FORMA QUE LA UNION EN EL AREA PREDETERMINADA EXPARCE EL AGENTE TERAPEUTICO EN LAS PROXIMIDADES. EL PRODUCTO PUEDE SER POR EJEMPLO, PARA EL CUIDADO DENTAL, TAL COMO PASTA DE DIENTES O ELIXIRES PARA EL ENJUAGADO DE BOCA Y EL FRAGMENTO DE ANTICUERPO PUEDE UNIRSE ENTONCES A UN COMPONENTE DE LA PLACA DENTAL. An antibody fragment able to bind to a target site is prolonged by an additional peptide. The therapeutic agent is bound to this peptide or means are provided to bring about such binding. The antibody fragment and possibly also the therapeutic agent are included in a product so that binding to the target site delivers the therapeutic agent to the vicinity. The product may for example be for dental care, such as a toothpaste or mouthwash and the antibody fragment may then bind to a component of dental plaque.