PROCESS FOR THE ISOLATION AND PURIFICATION OF MEVINOLIN

The present invention relates to a process for the isolation of mevinolin by dissolving the active ingredient from the biomass into the fermentation liquor and subsequently separating it from the filtered fermentation liquor, which comprises carrying out the dissolution at a pH value between 7.5 and...

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Bibliographic Details
Main Authors HO "GYE, IRMA, K RI, VILMOS, ILKO "Y, VA, BAGDI, ILONA, JEKKEL, ANTONIA, AMBRUS, GABOR
Format Patent
LanguageEnglish
Spanish
Published 01.03.1996
Edition6
Subjects
BEER
BIOCHEMISTRY
CHEMISTRY
ENZYMOLOGY
FERMENTATION OR ENZYME-USING PROCESSES TO SYNTHESISE A DESIREDCHEMICAL COMPOUND OR COMPOSITION OR TO SEPARATE OPTICAL ISOMERSFROM A RACEMIC MIXTURE
METALLURGY
MICROBIOLOGY
MUTATION OR GENETIC ENGINEERING
SPIRITS
VINEGAR
WINE
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Summary:The present invention relates to a process for the isolation of mevinolin by dissolving the active ingredient from the biomass into the fermentation liquor and subsequently separating it from the filtered fermentation liquor, which comprises carrying out the dissolution at a pH value between 7.5 and 10.0, preferably between 8.0 and 9.0, separating the active ingredient from the filtered liquor at a pH value between 4.5 and 1.0, preferably between 2.2 and 2.0, filtering and purifying it by methods known per se, preferably by recrystallization. PROCEDIMIENTO PARA EL AISLAMIENTO Y PURIFICACION DE MEVINOLINA. SE TRATA DE UN PROCEDIMIENTO PARA AISLAR MEVINOLINA DISOLVIENDO EL INGREDIENTE ACTIVO DE LA BIOMASA EN EL LICOR DE FERMENTACION Y SEPARANDOLO DESPUES DEL LICOR FILTRADO. CONSISTE EN LLEVAR LA SOLUCION A UN PH COMPRENDIDO ENTRE 7,5 Y 10, PREFERIBLEMENTE ENTRE 8,0 Y 9,0, SEPARAR EL INGREDIENTE ACTIVO DEL LICOR FILTRADO A UN PH COMPRENDIDO ENTRE 4,5 Y 1,0, PREFERIBLEMENTE ENTRE 2,2 Y 2,0, FILTRAR, Y PURIFICAR MEDIANTE METODOS CONOCIDOS, PREFERIBLEMENTE POR RECRISTALIZACION. LA DISOLUCION SE REALIZA EN PRESENCIA DE ADITIVOS EN CANTIDAD EQUIVALENTE COMO MINIMO AL 0,1 POR CIENTO DEL VOLUMEN DEL LICOR DE FERMENTACION. SE USAN COMO ADITIVOS ALCOHOLES ALIFATICOS CON 1 A 4 ATOMOS DE CARBONO, GLICOLES CON 2 A 5 ATOMOS DE CARBONO, AMINAS SECUNDARIAS O TERCIARIAS CON 1 A 3 ATOMOS DE CARBONO, ACETATOS DE ALQUILO CON 1 A 5 ATOMOS DE CARBONO, DIMETILFORMAMIDA, POLIETILENGLICOL, POLIPROPILENGLICOL, Y PREFERIBLEMENTE ETANOL O ETILENGLICOL. ANTESDE LA SEPARACION SE AÑADE AL LICOR FILTRADO UNA SAL DE METAL ALCALINOTERREO O TERREO.
Bibliography:Application Number: ES19940050018