NUEVOS INTERMEDIOS DE CEFALOSPORINA Y PROCESO PARA PREPARAR LOS INTERMEDIOS Y SUS PRODUCTOS FINALES

• Main Authors: KIM, YONG ZU, KIM, WON SUP, BANG, CHAN SIK, YEO, JAE HONG, LIM, JONG CHAN
• Format: Patent
• Language: Spanish
• Published: 01.09.1995
• Edition: 6
• Subjects: CHEMISTRY; HETEROCYCLIC COMPOUNDS; HUMAN NECESSITIES; HYGIENE; MEDICAL OR VETERINARY SCIENCE; METALLURGY; ORGANIC CHEMISTRY; PREPARATIONS FOR MEDICAL, DENTAL, OR TOILET PURPOSES; SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS ORMEDICINAL PREPARATIONS

ESTA INVENCION PROPORCIONA NUEVOS DERIVADOS DE CEFALOSPORINA REPRESENTADOS POR LA SIGUIENTE FORMULA (1), QUE SON ESPECIALMENTE UTILES COMO INTERMEDIARIOS PARA LA PREPARACION DE COMPUESTOS DE CEFALOSPORINA DOTADOS CON UNAS ACTIVIDADES ANTIBACTERIANAS POTENTES Y AMPLIAS. DONDE: R ELEVADO 1 UN ALQUILO C SUB 1-4, ALQUENILO C SUB 3-4, CICLOALQUILO C SUB 3-4, AMINO OPCIONALMENTE SUSTITUIDO CON UN RADICAL ALQUILO C SUB 1-4, O GRUPO FENILO OPCIONALMENTE SUSTITUIDO EN SU POSICION 2-, 4 UN HALOGENO, ALQUILO C SUB 1-4, ALCOXI C SUB 1-3 O RADICAL HIDROXI; R (AL CUADRADO) ES HIDROGENO O UN GRUPO ALQUILO C SUB 1-4; Y N ES BIEN 0 O 1. LA INVENCION TAMBIEN SE REFIERE A UN PROCESO PARA PREPARAR ESTOS INTERMEDIARIOS Y SUS ANTIBIOTICOS FARMACOLOGICAMENTE ACTIVOS DE CEFALOSPORINA ACTIVA. The present invention provides certain novel cephalosporin derivatives represented by following formula(I), which are especially useful as intermediates for the preparation of cephalosporin compounds possessed with potent and broad antibacterial activities. wherein: R is a C1-4alkyl, C3-4 alkenyl, C3-4 cycloalkyl, amino optionally substititued with a C1-4 alkyl radical, or phenyl group optionally subsitututed on its 2-, 4-and/or 6-position with a halogen, C1-4 alkyl, C1-3 alkoxy or hydroxy radical; R is hydrogen or a C1-4 alkyl group; and n is either 0 or 1. The invention also relates to processes for preparing these intermediates and their pharmacologically active cephalosporin antibiotics.