ARTICULOS MEDICOS ANTI-INFECCIOSOS Y LUBRICADOS Y SU PROCEDIMIENTO DE PREPARACION

• Main Authors: BYRON, PARKE M, SOLOMON, DONALD D
• Format: Patent
• Language: Spanish
• Published: 01.08.1994
• Edition: 4
• Subjects: CHEMICAL ASPECTS OF BANDAGES, DRESSINGS, ABSORBENT PADS, ORSURGICAL ARTICLES; CHEMISTRY; COMPOSITIONS BASED THEREON; COMPOSITIONS OF MACROMOLECULAR COMPOUNDS; DISINFECTION, STERILISATION, OR DEODORISATION OF AIR; HUMAN NECESSITIES; HYGIENE; MATERIALS FOR BANDAGES, DRESSINGS, ABSORBENT PADS, OR SURGICALARTICLES; MEDICAL OR VETERINARY SCIENCE; METALLURGY; METHODS OR APPARATUS FOR STERILISING MATERIALS OR OBJECTS INGENERAL; ORGANIC MACROMOLECULAR COMPOUNDS; PREPARATIONS FOR MEDICAL, DENTAL, OR TOILET PURPOSES; SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS ORMEDICINAL PREPARATIONS; THEIR PREPARATION OR CHEMICAL WORKING-UP; USE OF INORGANIC OR NON-MACROMOLECULAR ORGANIC SUBSTANCES ASCOMPOUNDING INGREDIENTS

UN ARTICULO MEDICO ANTIINFECCIOSO TIENE UNA MASA DE CLOROHEXIDINA DISTRIBUIDA EN LA TOTALIDAD DE UNA CAPA BASE DE POLIURETANO Y PUEDE TENER UNA CAPA DE REVESTIMIENTO SOBRE LA CAPA BASE. LA CAPA DE REVESTIMIENTO PUEDE ESTAR IMPREGNADA DE CLOROHEXIDINA DENTRO DE LA SUPERFICIE O PUEDE SER UN ANTIBIOTICO, AGENTE ANTITROMBOGENICO O UNA CAPA DE SUPERFICIE POLIMERICA LAMINADA SOBRE LA CAPA BASE. EL INVENTO INCLUYE UN METODO PARA PREPARAR EL ARTICULO POR EL CUAL SE PREPARA UNA FUNDICION HOMOGENEA DE POLIMERO Y CLOROHEXIDINA MEDIANTE UNA COMBINACION DE HELICES GEMELAS Y LA FUNDICION SE INYECTA PARA PRODUCIR UN ARTICULO SANITARIO QUE TIENE DISTRIBUIDO CLOROHEXIDINA EN SU MASA. An anti-infective medical article has chlorhexidine bulk distributed throughout a polyurethane base layer and may have a coating layer on the base layer. The coating layer may be chlorhexidine permeated into the surface or it may be an antibiotic, antithrombogenic agent or a polymeric surface layer laminated onto the base layer. The invention includes a method for preparing the article wherein a homogeneous melt of polymer and chlorhexidine is prepared by twin screw compounding and the melt is extruded to give a medical article having bulk distributed chlorhexidine.