MOLECULAS CON LUGARES DE COMBINACION DE ANTICUERPO QUE MUESTRAN PROPIEDADES CATALITICAS

• Main Authors: TRAMONTANO, ALFONSO, JANDA, KIM D, LERNER, RICHARD A
• Format: Patent
• Language: Spanish
• Published: 01.08.1994
• Edition: 4
• Subjects: ACYCLIC OR CARBOCYCLIC COMPOUNDS; ACYCLIC, CARBOCYCLIC OR HETEROCYCLIC COMPOUNDS CONTAININGELEMENTS OTHER THAN CARBON, HYDROGEN, HALOGEN, OXYGEN, NITROGEN,SULFUR, SELENIUM OR TELLURIUM; BEER; BIOCHEMISTRY; CHEMICAL OR PHYSICAL PROCESSES, e.g. CATALYSIS OR COLLOIDCHEMISTRY; CHEMISTRY; COMPOSITIONS THEREOF; CULTURE MEDIA; ENZYMOLOGY; FERMENTATION OR ENZYME-USING PROCESSES TO SYNTHESISE A DESIREDCHEMICAL COMPOUND OR COMPOSITION OR TO SEPARATE OPTICAL ISOMERSFROM A RACEMIC MIXTURE; HETEROCYCLIC COMPOUNDS; HUMAN NECESSITIES; HYGIENE; MEDICAL OR VETERINARY SCIENCE; METALLURGY; MICROBIOLOGY; MICROORGANISMS OR ENZYMES; MUTATION OR GENETIC ENGINEERING; ORGANIC CHEMISTRY; PEPTIDES; PERFORMING OPERATIONS; PHYSICAL OR CHEMICAL PROCESSES OR APPARATUS IN GENERAL; PREPARATIONS FOR MEDICAL, DENTAL, OR TOILET PURPOSES; PROCESSES USING MICROORGANISMS; PROPAGATING, PRESERVING OR MAINTAINING MICROORGANISMS; SPIRITS; THEIR RELEVANT APPARATUS; TRANSPORTING; VINEGAR; WINE

UN LIGANDO ANALOGO CON UNA CONFORMACION QUE SUSTANCIALMENTE SE CORRESPONDE CON LA CONFORMACION DE UN ESTADO DE TRANSICION HIDROLITICO DE UN LIGANDO REACTANTE DE AMIDA O DE ESTER QUE SE UTILIZA PARA AL PRODUCCION DE MOLECULAS RECEPTORAS CON UNA ESPECIFICIDAD PREDETERMINADA. LAS MOLECULAS RECEPTORAS INCLUYEN UN LADO QUE COMBINA ANTICUERPOS QUE SE ENLAZA A UN LIGANDO REACTANTE Y ASI ESTABILIZA AL ATOMO DE CARBONO TETRAEDRICO DEL ESTADO DE TRANSICION POR HIDROLISIS DE LA AMIDA O DEL ESTER DE ESE LIGANDO REACTANTE PARA HIDROLIZAR CATALITICAMENTE AL LIGANDO REACTANTE EN UN LUGAR PREDETERMINADO. An analog-ligand having a conformation that substantially corresponds to the conformation of a hydrolytic transition state of an amide or ester reactant ligand is used to produce receptor molecules of predetermined specificity. The receptor molecules include an antibody combining site that binds to a reactant ligand and thereby stabilizes the tetrahedral carbon atom of the amide or ester hydrolysis transition state of that reactant ligand to catalytically hydrolyze the reactant ligand at a predetermined site.