VIRAL PARTICLES TARGETING HEMATOPOIETIC STEM CELLS

Provided herein are targeted lipid particles, such as targeted lentiviral particles, having a targeting agent that binds to a target molecule selected from the group consisting of ASCT1, ASCT2, CD105, CD110, CD117, CD133, CD146, CD164, CD34, CD46, CD49f, CD90, EPCR, and ITGA3, and related polynucleo...

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Bibliographic Details
Main Authors STOPPATO, Matteo, BIASCO, Luca, CRUITE, Patricia
Format Patent
LanguageEnglish
French
German
Published 20.08.2025
Subjects
BEER
BIOCHEMISTRY
CHEMISTRY
COMPOSITIONS THEREOF
CULTURE MEDIA
ENZYMOLOGY
METALLURGY
MICROBIOLOGY
MICROORGANISMS OR ENZYMES
MUTATION OR GENETIC ENGINEERING
PROPAGATING, PRESERVING OR MAINTAINING MICROORGANISMS
SPIRITS
VINEGAR
WINE
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Summary:Provided herein are targeted lipid particles, such as targeted lentiviral particles, having a targeting agent that binds to a target molecule selected from the group consisting of ASCT1, ASCT2, CD105, CD110, CD117, CD133, CD146, CD164, CD34, CD46, CD49f, CD90, EPCR, and ITGA3, and related polynucleotides, cells, and methods for preparation and use of the targeted lipid particles, such as lenti viral particles. Also provided herein are methods involving mobilizing bone marrow cells in combination with administering targeted or non-targeted lipid particles, such as lentiviral particles, for treatment of a disease or condition in a subject.
Bibliography:Application Number: EP20230802116