CONDITIONING FOR IN VIVO IMMUNE CELL ENGINEERING

Disclosed are methods of conditioning subjects who receive, are receiving, or have received an agent for in vivo reprogramming of immune cells in order to improve the efficiency of the in vivo reprogramming and/or the overall therapeutic effect of the treatment. Also disclosed are nanoparticle compo...

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Bibliographic Details
Main Authors AGHAJANIAN, Haig, BOT, Adrian Ion
Format Patent
LanguageEnglish
French
German
Published 25.06.2025
Subjects
HUMAN NECESSITIES
HYGIENE
MEDICAL OR VETERINARY SCIENCE
PREPARATIONS FOR MEDICAL, DENTAL, OR TOILET PURPOSES
SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS ORMEDICINAL PREPARATIONS
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Summary:Disclosed are methods of conditioning subjects who receive, are receiving, or have received an agent for in vivo reprogramming of immune cells in order to improve the efficiency of the in vivo reprogramming and/or the overall therapeutic effect of the treatment. Also disclosed are nanoparticle compositions for providing the conditioning agent(s). The conditioning agent can be provided prior to, concurrently with, or after administration of the in vivo reprogramming agent depending on the conditioning agent. The conditioning regimens are useful in combination with in vivo reprogramming of immune cells to treat hematologic cancers and solid tumor, fibrotic disorders, and B cell or T cell mediated autoimmunity, chronic infection. Some conditioning regimens are also useful in combination with other cancer treatments.
Bibliography:Application Number: EP20230772707