DEVICE FOR DETERMINING AN INDICATOR OF PRESENCE OF HRD IN A GENOME OF A SUBJECT

The present invention relates to a device for determining an indicator of presence of Homologous Recombination Deficiency, HRD, in a genome of a subject, the device being configured for: receiving shallow WGS data and non-shallow sequencing data relative to a group of genes in the subject genome, ob...

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Bibliographic Details
Main Authors BERTAND, Denis, GOTTIN, Céline, DUFORET, Nicolas, BRUNEL, Samantha, BEAUMEUNIER, Sacha, RUZICKA, Jiri, PHILIPPE, Nicolas
Format Patent
LanguageEnglish
French
German
Published 30.04.2025
Subjects
INFORMATION AND COMMUNICATION TECHNOLOGY [ICT] SPECIALLY ADAPTEDFOR SPECIFIC APPLICATION FIELDS
PHYSICS
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Summary:The present invention relates to a device for determining an indicator of presence of Homologous Recombination Deficiency, HRD, in a genome of a subject, the device being configured for: receiving shallow WGS data and non-shallow sequencing data relative to a group of genes in the subject genome, obtaining at least one first parameter from the shallow WGS data and at least one second parameter from non-shallow sequencing data, and determining, by applying a Machine Learning Model to the obtained at least first and second parameters, an indicator of presence of HRD in the subject genome.
Bibliography:Application Number: EP20230735280