METHODS FOR THE ENHANCEMENT OF THERAPEUTIC EFFECT OF CAR-T CELLS

Provided herein is the use of LSD1 inhibitors, in particular bomedemstat, in connection with use and manufacture of immune effector cells such as NK cells and T cells engineered to express a chimeric antigen receptor (CAR), to treat a subject having a disease, associated with expression of a tumor a...

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Bibliographic Details
Main Author RIENHOFF, Hugh, Y., Jr
Format Patent
LanguageEnglish
French
German
Published 26.03.2025
Subjects
CHEMISTRY
HUMAN NECESSITIES
HYGIENE
MEDICAL OR VETERINARY SCIENCE
METALLURGY
ORGANIC CHEMISTRY
PEPTIDES
PREPARATIONS FOR MEDICAL, DENTAL, OR TOILET PURPOSES
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Summary:Provided herein is the use of LSD1 inhibitors, in particular bomedemstat, in connection with use and manufacture of immune effector cells such as NK cells and T cells engineered to express a chimeric antigen receptor (CAR), to treat a subject having a disease, associated with expression of a tumor antigen.
Bibliography:Application Number: EP20230808604