8-AZA QUINAZOLINES AS BRAIN-PENETRANT SOS1-INHIBITORS

• Main Authors: MUELLER, Stephan Georg, WUNBERG, Tobias, GIOVANNINI, Riccardo, HEINE, Niklas, HOHN, Christoph, RAMHARTER, Juergen
• Format: Patent
• Language: English; French; German
• Published: 30.10.2024
• Subjects: CHEMISTRY; HETEROCYCLIC COMPOUNDS; HUMAN NECESSITIES; HYGIENE; MEDICAL OR VETERINARY SCIENCE; METALLURGY; ORGANIC CHEMISTRY; PREPARATIONS FOR MEDICAL, DENTAL, OR TOILET PURPOSES; SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS ORMEDICINAL PREPARATIONS

The present invention relates to small molecules capable of inhibiting SOS1 (Son of Sevenless) and their salts. Specifically, the present invention relates to heterocyclic compounds of general formula (I) or salts thereof wherein A, X, R1, R2, R3 have one of the meanings as indicated in the specific...