8-AZA QUINAZOLINES AS BRAIN-PENETRANT SOS1-INHIBITORS

The present invention relates to small molecules capable of inhibiting SOS1 (Son of Sevenless) and their salts. Specifically, the present invention relates to heterocyclic compounds of general formula (I) or salts thereof wherein A, X, R1, R2, R3 have one of the meanings as indicated in the specific...

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Bibliographic Details
Main Authors MUELLER, Stephan Georg, WUNBERG, Tobias, GIOVANNINI, Riccardo, HEINE, Niklas, HOHN, Christoph, RAMHARTER, Juergen
Format Patent
LanguageEnglish
French
German
Published 30.10.2024
Subjects
CHEMISTRY
HETEROCYCLIC COMPOUNDS
HUMAN NECESSITIES
HYGIENE
MEDICAL OR VETERINARY SCIENCE
METALLURGY
ORGANIC CHEMISTRY
PREPARATIONS FOR MEDICAL, DENTAL, OR TOILET PURPOSES
SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS ORMEDICINAL PREPARATIONS
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Summary:The present invention relates to small molecules capable of inhibiting SOS1 (Son of Sevenless) and their salts. Specifically, the present invention relates to heterocyclic compounds of general formula (I) or salts thereof wherein A, X, R1, R2, R3 have one of the meanings as indicated in the specification. Furthermore, the invention relates to pharmaceutical compositions and combinations comprising these compounds, as well as their use in methods for the treatment of diseases associated with or modulated by SOS1.
Bibliography:Application Number: EP20220843257