LIVER-SPECIFIC CAR FOR USE AGAINST IMMUNOLOGIC REJECTION
The present invention relates to a CAR and to regulatory T-cells (Treg) expressing the CAR, especially for use in the treatment, especially for suppression, of adverse immune reactions against liver tissue, e.g. for use in the treatment of host-versus-graft disease (HvG) against a liver transplant,...
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Main Authors | , , |
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Format | Patent |
Language | English French German |
Published |
09.10.2024
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Subjects | |
Online Access | Get full text |
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Summary: | The present invention relates to a CAR and to regulatory T-cells (Treg) expressing the CAR, especially for use in the treatment, especially for suppression, of adverse immune reactions against liver tissue, e.g. for use in the treatment of host-versus-graft disease (HvG) against a liver transplant, for use in the treatment of an autoimmune disease directed against liver tissue, or for use in the treatment of inflammatory liver disorder. The invention provides a chimeric antigen receptor (CAR) that comprises an scFv portion, which is specific for the asialoglycoprotein receptor (ASGPR). |
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Bibliography: | Application Number: EP20230167117 |