ANNULATED 2-AMINO-3-CYANO THIOPHENES AND DERIVATIVES FOR THE TREATMENT OF CANCER

The present invention encompasses compounds of formula (I)wherein R1a, R1b, R2a, R2b, Z, R3 to R5, A, p, U, V and W have the meanings given in the claims and specification, their use as inhibitors of KRAS, pharmaceutical compositions and preparations containing such compounds and their use as medica...

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Main Authors MANTOULIDIS, Andreas, SARKAR, Dhruba, TREU, Matthias, LITTLE, Andrew, PHAN, Jason, BROEKER, Joachim, SMETHURST, Christian Alan Paul, SOKOL, Kevin, STADTMUELLER, Heinz, SUN, Qi, WILDING, Birgit, CUI, Jianwen, FUCHS, Julian, RAMHARTER, Juergen, WATERSON, Alex, HERDEIS, Lorenz, FESIK, Stephen W, WUNBERG, Tobias, ABBOTT, Jason, HODGES, Tim, GOLLNER, Andreas
Format Patent
LanguageEnglish
French
German
Published 09.10.2024
Subjects
CHEMISTRY
HETEROCYCLIC COMPOUNDS
HUMAN NECESSITIES
HYGIENE
MEDICAL OR VETERINARY SCIENCE
METALLURGY
ORGANIC CHEMISTRY
PREPARATIONS FOR MEDICAL, DENTAL, OR TOILET PURPOSES
SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS ORMEDICINAL PREPARATIONS
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Summary:The present invention encompasses compounds of formula (I)wherein R1a, R1b, R2a, R2b, Z, R3 to R5, A, p, U, V and W have the meanings given in the claims and specification, their use as inhibitors of KRAS, pharmaceutical compositions and preparations containing such compounds and their use as medicaments/medical uses, especially as agents for treatment and/or prevention of oncological diseases.
Bibliography:Application Number: EP20220823522