RXFP1 AGONISTS

The disclosure relates to compounds of Formula (I), which are RXFP1 receptor agonists, compositions containing them, and methods of using them, for example, in the treatment of heart failure, fibrotic diseases, and related diseases such as lung disease (e.g., idiopathic pulmonary fibrosis), kidney d...

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Bibliographic Details
Main Authors CLARKE, Adam James, WURTZ, Nicholas R, PABBISETTY, Kumar Balashanmuga, MYERS, Michael C, LI, Jianqing, SU, Shun, FRIENDS, Todd J, PASUNOORI, Laxman, PINTO, Donald J.P, SHAW, Scott A, TORA, George O, MATHUR, Arvind, VOKITS, Benjamin P
Format Patent
LanguageEnglish
French
German
Published 04.09.2024
Subjects
ACYCLIC OR CARBOCYCLIC COMPOUNDS
CHEMISTRY
HETEROCYCLIC COMPOUNDS
HUMAN NECESSITIES
HYGIENE
MEDICAL OR VETERINARY SCIENCE
METALLURGY
ORGANIC CHEMISTRY
PREPARATIONS FOR MEDICAL, DENTAL, OR TOILET PURPOSES
SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS ORMEDICINAL PREPARATIONS
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Summary:The disclosure relates to compounds of Formula (I), which are RXFP1 receptor agonists, compositions containing them, and methods of using them, for example, in the treatment of heart failure, fibrotic diseases, and related diseases such as lung disease (e.g., idiopathic pulmonary fibrosis), kidney disease (e.g., chronic kidney disease), or hepatic disease (e.g., non-alcoholic steatohepatitis and portal hypertension).
Bibliography:Application Number: EP20220835522