PYRIDINYLACETAMIDE DERIVATIVES AS SODIUM CHANNEL ACTIVATORS

The present disclosure is directed to compounds of formula (I):wherein R1, R2, R3, R3a, R4, Y, and X are as described herein, as stereoisomers, enantiomers, or tautomers thereof or mixtures thereof; or pharmaceutically acceptable salts, solvates, or prodrugs thereof, and pharmaceutical compositions...

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Main Authors SCHOLTES, Jan Felix, WESOLOWSKI, Steve, RAJAMANI, Ramkumar, KIM, Jung Yun, SUN, Shaoyi, CLEMENT, Helen, JOHNSTONE, Shawn, CLARK, Michael, SABBATANI, Juliette, CHARIFSON, Paul, BURFORD, Kristen, MUNUGANTI, Ravi, ZHANG, Wei, LOFSTRAND, Verner
Format Patent
LanguageEnglish
French
German
Published 31.07.2024
Subjects
CHEMISTRY
HETEROCYCLIC COMPOUNDS
METALLURGY
ORGANIC CHEMISTRY
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Summary:The present disclosure is directed to compounds of formula (I):wherein R1, R2, R3, R3a, R4, Y, and X are as described herein, as stereoisomers, enantiomers, or tautomers thereof or mixtures thereof; or pharmaceutically acceptable salts, solvates, or prodrugs thereof, and pharmaceutical compositions comprising the compounds of formula (I), as described herein, which are useful as voltage-gated sodium channel modulators and are therefore are useful in treating seizure disorders such as epilepsy.
Bibliography:Application Number: EP20220792990