DETECTION OF B CELL ANTIBODY RESPONSES IN PATIENTS WITH HAEMOPHILIA AND TREATMENT THEREOF

Embodiments of this disclosure include in vitro tests to detect clotting factor-specific antibodies produced by B cells from peripheral blood mononuclear cells (PBMCs) in patients with haemophilia that develop resistance to substitution therapy. Additional embodiments include therapeutic methods for...

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Bibliographic Details
Main Authors SHOWALTER, Loral, LEHMANN, Paul
Format Patent
LanguageEnglish
French
German
Published 10.07.2024
Subjects
CHEMISTRY
HUMAN NECESSITIES
HYGIENE
INVESTIGATING OR ANALYSING MATERIALS BY DETERMINING THEIRCHEMICAL OR PHYSICAL PROPERTIES
MEASURING
MEDICAL OR VETERINARY SCIENCE
METALLURGY
ORGANIC CHEMISTRY
PEPTIDES
PHYSICS
PREPARATIONS FOR MEDICAL, DENTAL, OR TOILET PURPOSES
SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS ORMEDICINAL PREPARATIONS
TESTING
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Summary:Embodiments of this disclosure include in vitro tests to detect clotting factor-specific antibodies produced by B cells from peripheral blood mononuclear cells (PBMCs) in patients with haemophilia that develop resistance to substitution therapy. Additional embodiments include therapeutic methods for treating patients with haemophilia who have been identified at risk of developing B cell mediated resistance to clotting factor-reconstitution (or substitution) therapy, or have developed resistance to such therapy, by selectively inactivating the B cells that produce clotting factor-specific antibodies, and monitoring the efficiency of the latter treatment by measuring the residual clotting factor-specific B cells in these subjects.
Bibliography:Application Number: EP20220865244