BISPECIFIC MOLECULE SPECIFICALLY BINDING TO B7-H3 AND TGF? AND USES THEREOF

The present invention relates to a bispecific molecule including: B7-H3 antibody or antigen-binding fragment thereof; and a TGFβ binding portion bound thereto, more particularly, to a bispecific molecule which is bispecifically bound to B7-H3 and TGFβ and thus can be utilized as an immune checkpoint...

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Bibliographic Details
Main Authors LEE, Jung Wook, PARK, Dong Woon, LEE, Jung Eun, JUNG, Byung Hun
Format Patent
LanguageEnglish
French
German
Published 03.07.2024
Subjects
CHEMISTRY
HUMAN NECESSITIES
HYGIENE
MEDICAL OR VETERINARY SCIENCE
METALLURGY
ORGANIC CHEMISTRY
PEPTIDES
PREPARATIONS FOR MEDICAL, DENTAL, OR TOILET PURPOSES
SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS ORMEDICINAL PREPARATIONS
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Summary:The present invention relates to a bispecific molecule including: B7-H3 antibody or antigen-binding fragment thereof; and a TGFβ binding portion bound thereto, more particularly, to a bispecific molecule which is bispecifically bound to B7-H3 and TGFβ and thus can be utilized as an immune checkpoint inhibitor for various diseases including cancer.
Bibliography:Application Number: EP20220861769