SELF DEGRADATION-TYPE CDK9 INHIBITOR PRODRUG AND LIPOSOME ENCAPSULATING SAME

Provided is a self-degradation type CDK9 inhibitor prodrug and a liposome encapsulating the same. The present disclosure provides a compound represented by formula (1) or a pharmaceutically acceptable salt thereof:wherein R1 is an optionally substituted C1-6 alkyl group, R2 and R3 are the same or di...

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Bibliographic Details
Main Authors MATSUOKA, Makoto, SHIMADA, Naoaki, BAN, Hitoshi, KAMIOKA, Seiji
Format Patent
LanguageEnglish
French
German
Published 03.07.2024
Subjects
CHEMISTRY
HETEROCYCLIC COMPOUNDS
HUMAN NECESSITIES
HYGIENE
MEDICAL OR VETERINARY SCIENCE
METALLURGY
ORGANIC CHEMISTRY
PREPARATIONS FOR MEDICAL, DENTAL, OR TOILET PURPOSES
SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS ORMEDICINAL PREPARATIONS
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Summary:Provided is a self-degradation type CDK9 inhibitor prodrug and a liposome encapsulating the same. The present disclosure provides a compound represented by formula (1) or a pharmaceutically acceptable salt thereof:wherein R1 is an optionally substituted C1-6 alkyl group, R2 and R3 are the same or different, each independently a hydrogen atom or an optionally substituted C1-6 alkyl group, X is CH2 or an oxygen atom, n is 1 or 2, p is 0, 1 or 2, q is 1 or 2, and r is 0, 1 or 2, wherein, if X is an oxygen atom, q is 2.
Bibliography:Application Number: EP20220861320